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  1. No Access

    Article

    TNF-α-converting enzyme (TACE/ADAM17)-dependent loss of CD30 induced by proteasome inhibition through reactive oxygen species

    Combinations with proteasome inhibitors are currently being investigated to improve the therapy of hematological malignancies. We previously found that proteasome inhibition by bortezomib failed to sensitize a...

    A M Vahdat, K S Reiners, V L Simhadri, D A Eichenauer, B Böll, A Chalaris… in Leukemia (2010)

  2. Article

    BCL-xL: time-dependent dissociation between modulation of apoptosis and invasiveness in human malignant glioma cells

    Conditionally BCL-xL-overexpressing LNT-229 Tet-On glioma cell clones were generated to investigate whether the ‘antiapoptosis phenotype’ and the ‘motility phenotype’ mediated by BCL-2 family proteins in glioma c...

    M Weiler, O Bähr, U Hohlweg, U Naumann, J Rieger, H Huang… in Cell Death & Differentiation (2006)

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  3. No Access

    Article

    Matrix metalloproteinase-9 is elevated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice

    Matrix metalloproteinases (MMPs) are proteolytic enzymes capable of degrading components of the extracellular matrix. Recent evidence has implicated MMPs in the pathogenesis of neurodegenerative diseases as Al...

    Stefan Lorenzl, Noel Calingasan, Lichuan Yang, David S. Albers… in NeuroMolecular Medicine (2004)

  4. No Access

    Chapter and Conference Paper

    Verbesserung der Wundheilung durch lokale Proteasenhemmung

    Proteasen, und hierbei insbesondere die Gruppe der Matrix-Metalloproteasen (MMPs), sind in allen Phasen der Wundheilung maßgeblich an Gewebeumbau-Prozessen beteiligt. Eine Störung des Gleichgewichtes zwischen ...

    O. Safak, N. Dagdelen, C. Volkering, A. Botzlar, A. Pfadenhauer… in Zurück in die Zukunft (2003)

  5. No Access

    Chapter and Conference Paper

    Lokale Hemmung der Matrixmetalloproteinaseaktivität zur Verbesserung der verzögerten Wundheilung im Tiermodell

    Increased proteinase activity seems to be mainly responsible for impaired healing in chronic wounds. Topical application of matrix metalloproteinase (MMPs) inhibitors, with the objective to reestablish the phy...

    Okan Safak, N. Dagdelen, C. Volkering… in Chirurgisches Forum 2003 für experimentell… (2003)

  6. No Access

    Article

    The novel synthetic inhibitor of matrix metalloproteinases Ro 28-2653 induces apoptosis in Dunning tumor cells

    The effect of synthetic inhibitors of matrix metalloproteinases (MMP) has been shown against a variety of tumors in preclinical models. Ro 28-2653, a novel synthetic MMP inhibitor, is able to reduce tumor grow...

    D. Mangoldt, B. Sinn, M. Lein, H. W. Krell, D. Schnorr, S. A. Loening, K. Jung in Apoptosis (2002)