-
Article
Open AccessAuthor Correction: Universal DNA methylation age across mammalian tissues
-
Article
Open AccessUniversal DNA methylation age across mammalian tissues
Aging, often considered a result of random cellular damage, can be accurately estimated using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we demonstrate the development of u...
-
Article
Open AccessVariable Anisotropic Brain Electrical Conductivities in Epileptogenic Foci
Source localization models assume brain electrical conductivities are isotropic at about 0.33 S/m. These assumptions have not been confirmed ex vivo in humans. This study determined bidirectional electrical co...
-
Chapter
Cerebrovascular Disease — Practical Issues in Surgical and Autopsy Pathology
This chapter will deal with practical approaches to the pathologic diagnosis of cerebrovascular diseases. Many forms of ‘stroke’ and cerebrovascular disease pay little respect to arbitrary boundaries defined b...
-
Chapter and Conference Paper
Clinical and Neuropathological Features in AIDS Patients with Progressive Multifocal Leukoencephalopathy (PML) Including a Novel Approach by in situ PCR
Opportunistic infection of the central nervous system by human Polyomavirus JC (JCV) can cause a devastating disease, progressive multifocal leukoencephalopathy (PML). We reviewed the clinical features of 15 pati...
-
Article
Congenital olivopontocerebellar atrophy: report of two siblings with paleo- and neocerebellar atrophy
We report two sisters with congenital olivopontocerebellar atrophy, including immunohistochemical studies of autopsy brain tissue. Both cases showed microcephaly with disproportionately marked hypoplasia of t...
-
Article
Tuberous sclerosis in a 20-week gestation fetus: immunohistochemical study
We report an autopsy case of tuberous sclerosis complex (TSC) in a 20-week gestational age female fetus. The brain showed lesions suggestive of early cortical tubers and subependymal hamartomatous nodules. Th...
-
Article
Neuronal cytoskeletal abnormalities in human cerebral cortical dysplasia
The cytoskeletal abnormalities of cortical neurons in human cerebral cortical dysplasia were compared by immunohistochemical methods to the neurofibrillary tangles of Alzheimer's disease (AD). Surgical specime...
-
Article
Acute varicella-zoster virus ventriculitis and mengingo-myelo-radiculitis in acquired immunodeficiency syndrome
A 30-year-old AIDS patient with no history of cutaneous eruption, presented with rapidly progressive flaccid paraplegia, hypoesthesia, urinary retention, moderate psychomotor slowing and fever (39.8°C), leadin...
-
Article
The pathology of arteriovenous malformations of the brain treated by embolotherapy
Light microscopic and immunohistochemical examination was undertaken of intracranial arteriovenous malformations (AVMs) surgically resected from 18 patients, each of whom had undergone preoperative angiographi...
-
Article
Correlation of neuromuscular pathology in acquired immune deficiency syndrome patients with cytomegalovirus infection and zidovudine treatment
Peripheral nerve and skeletal muscle specimens from 115 autopsied adult AIDS patients were examined for types and incidence of histological abnormalities. Focal perivascular chronic inflammatory infiltrates fe...
-
Article
Neuropathologic findings in cortical resections (including hemispherectomies) performed for the treatment of intractable childhood epilepsy
Despitè the use of hemispherectomy in the treatment of medically refractory seizures since the early 1950's, few studies published have documented neuropathologic findings in the resected specimens. This repor...
-
Article
Use of a new mixture for embolization of intracranial vascular malformations
The internal carotid artery system in swine has a special anatomic configuration similar to a brain “arterial-arterial malformation”. The internal carotid artery breaks up into a multitude of fine channels (re...
-
Article
Severe neuropathy in a patient with acquired immune deficiency syndrome (AIDS)
A patient with acquired immune deficiency syndrome (AIDS) developed a progressive neuromuscular disorder which included a sensory component, severe weakness and muscle wasting, and fasciculations. At autopsy, ...
-
Article
Stroke related to cerebral amyloid angiopathy: the significance of systemic vascular disease
A retrospective postmortem analysis of 25 cases of cerebral amyloid angiopathy (CAA) in the setting of Alzheimer's disease or senile dementia of the Alzheimer type (AD/SDAT) is reported. Seven patients experie...
-
Article
Evidence for human immunodeficiency virus (HIV) infection of the brain in a patient with aplastic anemia
A young female patient with a long history of intravenous drug abuse died after a fulminant course of aplastic anemia. At postmortem examination, she was found to have multinucleate giant cells and immunocytoc...
-
Article
The pathology of encephalic arteriovenous malformations treated by prior embolotherapy
A pathologic study was undertaken of seven encephalic arteriovenous malformations, including five resected from one to seven days after balloon embolization, one resected 10 days after embolization with polyvi...
-
Article
Severe cerebellar degeneration in a patient with T-cell lymphoma
A 53-year-old man with an aggressive T-cell lymphoma was found at autopsy to have severe cerebellar degeneration, presumably as a ‘remote’ effect of malignancy. The degree of cerebellar atrophy was unusually p...
-
Article
The histotoxicity of cyanoacrylates
Cyanoacrylates, a group of rapidly polymerizing adhesives, have found widespread uses in oral and general surgery as well as surgical subspecialties, for example as hemostatic and anastomotic agents. They have...
-
Article
Hydrocephalus with cerebral aqueductal dysgenesis and craniofacial anomalies
A pre-term infant was born with multiple limb and craniofacial anomalies, including craniosynostosis and a nasopharyngeal adenohypophysis. Severe hydrocephalus of the lateral and third ventricles was attribute...
