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  1. Article

    Open Access

    Oxytocin efficacy is modulated by dosage and oxytocin receptor genotype in young adults with high-functioning autism: a 24-week randomized clinical trial

    Recent studies have suggested that long-term oxytocin administration can alleviate the symptoms of autism spectrum disorder (ASD); however, factors influencing its efficacy are still unclear. We conducted a si...

    H Kosaka, Y Okamoto, T Munesue, H Yamasue, K Inohara, T Fujioka… in Translational Psychiatry (2016)

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  2. Article

    Open Access

    The hnRNP-Htt axis regulates necrotic cell death induced by transcriptional repression through impaired RNA splicing

    In this study, we identify signaling network of necrotic cell death induced by transcriptional repression (TRIAD) by α-amanitin (AMA), the selective RNA polymerase II inhibitor, as a model of neurodegenerative ce...

    Y Mao, T Tamura, Y Yuki, D Abe, Y Tamada, S Imoto, H Tanaka… in Cell Death & Disease (2016)

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  3. Article

    Open Access

    In utero gene therapy rescues microcephaly caused by Pqbp1-hypofunction in neural stem progenitor cells

    Human mutations in PQBP1, a molecule involved in transcription and splicing, result in a reduced but architecturally normal brain. Examination of a conditional Pqbp1-knockout (cKO) mouse with microcephaly failed ...

    H Ito, H Shiwaku, C Yoshida, H Homma, H Luo, X Chen, K Fujita… in Molecular Psychiatry (2015)

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  4. No Access

    Reference Work Entry In depth

    Polyglutamine Diseases

    Polyglutamine diseases are a major group of neurodegeneration induced by mutant proteins containing an expanded polyglutamine tract sequence. In this chapter, recent findings on aggregation process and metabol...

    H. Okazawa in Handbook of Neurochemistry and Molecular Neurobiology (2007)

  5. No Access

    Article

    Polyglutamine diseases: a transcription disorder?

    Various molecular processes including unfolded protein response, protein transport, synaptic transmission and transcription are implicated in the pathology of polyglutamine diseases caused by the expanded po...

    H. Okazawa in Cellular and Molecular Life Sciences CMLS (2003)

  6. Article

    Identification of a single nucleotide polymorphism showing no insulin-mediated suppression of the promoter activity in the human insulin receptor substrate 2 gene

    Abstract

    K. Iwamoto, H. Mori, H. Okazawa, M. Hashiramoto, M. Kasuga in Diabetologia (2002)

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  7. Article

    A polymorphism in the 5' untranslated region and a Met229→ Leu variant in exon 5 of the human UCP1 gene are associated with susceptibility to Type II diabetes mellitus

    Aims/hypothesis. The cumulative effects of several thrifty factors could contribute to the pathogenesis of Type II (non-insulin-dependent) diabetes mellitus. We screened the human UCP1 gene (UCP1

    H. Mori, H. Okazawa, K. Iwamoto, E. Maeda, M. Hashiramoto, M. Kasuga in Diabetologia (2001)

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  8. No Access

    Article

    [18F]-Fluorodeoxyglucose-positron emission tomography findings in preterm infants with severe periventricular leukomalacia and hypsarrhythmia

    Two preterm infants with extensive periventricular leukomalacia (PVL) were examined by [18F]-fluorodeoxyglucose-positron emission tomography (FDG-PET) at the corrected ages of 18 and 34 days. They showed similar...

    Y. Higuchi, T. Maihara, H. Hattori, K. Furusho… in European Journal of Pediatrics (1997)

  9. No Access

    Chapter and Conference Paper

    Work on Primary Cesium Beam Frequency Standard at CRL

    Initially, beam tube experiments adopted an H-plane-bend Ramsey cavity using an E-plane feed and a solenoid coil to make a uniform C-field [1], [2]. This system is similar to the Cs 1 and 2 atomic clocks at PT...

    K. Nakagiri, M. Shibuki, H. Okazawa, M. Aida… in Frequency Standards and Metrology (1989)

  10. No Access

    Article

    Studies on retrograde cholecystography in hepato-biliary disoders

    T. Fujita, K. Nakamura, T. Takenaka, K. Sasayama, T. Mito… in Gastroenterologia Japonica (1967)