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Article
Fever-triggered ventricular arrhythmias in Brugada syndrome and type 2 long-QT syndrome
The risk for lethal ventricular arrhythmias is increased in individuals who carry mutations in genes that encode cardiac ion channels. Loss-of-function mutations in SCN5A, the gene encoding the cardiac sodium cha...
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Article
Pregnancy and the risk of torsades de pointes in congenital long-QT syndrome
Patients with congenital long-QT syndrome (LQTS) are at increased risk of ventricular arrhythmias during stressful situations. Large-scale studies have pointed out that affected individuals are particularly at...
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Article
Short-coupled variant of torsade de pointes
A 36-year-old man with a history of primary sclerosing cholangitis and epilepsy was admitted to our hospital for cholangitis. During admission he was resuscitated because of ventricular fibrillation. ECGs show...
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Article
Left superior vena cava, a remnant of embryological development
A 46-year-old Brugada syndrome patient underwent insertion of a dual-chamber implantable cardioverter- defibrillator (ICD), revealing a left-sided superior vena cava (SVC), (figure 1), running, characteristica...
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Article
Gender disparities in torsade de pointes ventricular tachycardia
Background Gender disparities in the incidence of torsade de pointes (TdP) ventricular tachycardia exist, but the mechanisms in humans are unresolved. We addressed this issue using a mathematical model of a human...