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Open AccessRationale and design of the PHOspholamban RElated CArdiomyopathy intervention STudy (i-PHORECAST)
The p.Arg14del (c.40_42delAGA) phospholamban (PLN) pathogenic variant is a founder mutation that causes dilated cardiomyopathy (DCM) and arrhythmogenic cardiomyopathy (ACM). Carriers are at increased risk of m...
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Open AccessPatient perspectives on priorities for research on conventional and sex- and gender-related cardiovascular risk factors
Recently, cardiovascular disease (CVD) research has focused on sex- and gender-related cardiovascular risk factors, in addition to conventional risk factors. This raises the question which factors are perceive...
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Open AccessAtrial fibrillation mimicking ventricular fibrillation confuses an automated external defibrillator
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In-hospital haloperidol use and perioperative changes in QTc-duration
Haloperidol may prolong ECG QTc-duration but is often prescribed perioperatively to hip-fracture patients. We aimed to determine (1) how QTc-duration changes perioperatively, (2) whether low-dose haloperidol-u...
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Article
Fever-triggered ventricular arrhythmias in Brugada syndrome and type 2 long-QT syndrome
The risk for lethal ventricular arrhythmias is increased in individuals who carry mutations in genes that encode cardiac ion channels. Loss-of-function mutations in SCN5A, the gene encoding the cardiac sodium cha...
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Pregnancy and the risk of torsades de pointes in congenital long-QT syndrome
Patients with congenital long-QT syndrome (LQTS) are at increased risk of ventricular arrhythmias during stressful situations. Large-scale studies have pointed out that affected individuals are particularly at...
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Short-coupled variant of torsade de pointes
A 36-year-old man with a history of primary sclerosing cholangitis and epilepsy was admitted to our hospital for cholangitis. During admission he was resuscitated because of ventricular fibrillation. ECGs show...
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Article
Left superior vena cava, a remnant of embryological development
A 46-year-old Brugada syndrome patient underwent insertion of a dual-chamber implantable cardioverter- defibrillator (ICD), revealing a left-sided superior vena cava (SVC), (figure 1), running, characteristica...
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Gender disparities in torsade de pointes ventricular tachycardia
Background Gender disparities in the incidence of torsade de pointes (TdP) ventricular tachycardia exist, but the mechanisms in humans are unresolved. We addressed this issue using a mathematical model of a human...
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Article
Biological pacing by gene and cell therapy
At present, cardiac rhythm disorders such as sick sinus syndrome (SSS) or AV nodal block (AVB) are usually treated by electronic pacemakers. These devices have significant shortcomings, including lack of auton...
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Article
The role of diagnostic laparoscopy in micropremmies with suspected necrotizing enterocolitis
The timely diagnosis of perforations or dead gut can be extremely difficult in micropremmies with necrotizing enterocolitis. A negative laparotomy is just as detrimental as failure to recognize early perforati...
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Laparoscopic surgery in children is associated with an intraoperative hypermetabolic response
Laparoscopic surgery is thought to be associated with a reduced metabolic response compared to open surgery. Oxygen consumption ( ...
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Lymphatic sparing, laparoscopic varicocelectomy: a new surgical technique
Several surgical options are available for managing varicoceles. Although conventional surgery offers good surgical results, the most common long-term complication of surgery is the development of hydroceles, ...
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Article
Laparoscopic resection of type I choledochal cyst
Type I choledochal cyst is a rare saccular or fusiform congenital dilatation of the extrahepatic biliary tract. It is usually treated by laparotomy at which the cyst is completely excised and a Roux-en-Y hepat...
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The successful medical management of severe duodenal strictures secondary to eosinophilic gastroenteritis in an infant
Eosinophilic gastroenteritis is an uncommon condition of unknown etiology that has only been relatively recently reported. Its clinical manifestations range from a mild disease to more severe forms resembling ...
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Ectopic pancreatic rests: a rare cause of persistent umbilical discharge
Ectopic pancreatic rests are rare. We report two cases discovered in infants who underwent surgical exploration of the umbilicus for persistent umbilical discharge with peri-umbilical excoriation. A shallow s...
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Letter to the editor
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Laparoscopic bipolar strip-tease appendicectomy
Since its conception, several techniques have been described for laparoscopic appendicectomy. We describe a technique which utilizes a 5-mm bipolar forceps designed to coagulate and cut tissues at the same tim...
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Initial experience with laparoscopic adhesiolysis in children
Intra-abdominal adhesions are a well-known complication of laparotomy. We report our initial experience of ten children undergoing laparoscopy for the diagnosis and treatment of intra-abdominal adhesions. Sign...
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Laparoscopic pyloromyotomy for infantile hypertrophic pyloric stenosis
Although great advances in laparoscopic techniques have been made in the field of adult surgery, its application in infants and young children has been limited. We present a technique of laparoscopic pyloromyo...