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Article
Open AccessTorasemide significantly reduces thiazide-induced potassium and magnesium loss despite supra-additive natriuresis
Resistance to high-dose loop diuretics can be overcome either by co-administration with thiazides or by treatment with medium-dose loop diuretics combined with thiazides. Combination therapy has been proven to...
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Article
The influence of cardiovascular and antiinflammatory drugs on thiazide-induced hemodynamic and saluretic effects
Thiazide diuretics are known to induce a transient fall of the glomerular filtration rate (GFR), which, in turn, reduces tubular Na+ load. This tubuloglomerular feedback (TGF) curtails the natriuretic effect of t...
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Chapter
Therapie der essenziellen Hypertonie
Es ist unstrittig, dass lebensstiländernde Maßnahmen den erhöhten Blutdruck erheblich senken und vor allen Dingen in ihrer Komplexität unter Verwendung verschiedener Strategien den Effekt einer medikamentösen ...
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Chapter
Thiazide Diuretics
Thiazide diuretics have been in existence for more than 3 decades. They are benzothiadiazines or analogs and derivatives of the carbonic anhydrase–inhibiting sulfonamides. Their synthesis was spawned by a sear...
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Chapter
Potassium-Retaining Diuretics: Triamterene
Triamterene belongs to the class of cyclic amidine diuretics along with amiloride. The core structure of triamterene (Fig. 3) is a pteridine ring which is substituted in the 2, 4, and 7 positions by amino grou...
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Article
The saluretic effect of the thiazide diuretic bemetizide in relation to the glomerular filtration rate
The effect of the thiazide diuretic, bemetizide, on the excretion of Na+, K+, Cl−, Ca2+, and Mg2+ in relation to the glomerular filtration rate (GFR) was studied in 17 subjects whose creatinine clearances ranged ...
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Article
Pharmacodynamic and kinetic considerations on diuretics as a basis for differential therapy
Diuretics are classified according to their site of action in the nephron: loop diuretics, thiazides, and antikaliuretics. During peak diuresis the pattern of electrolyte excretion is constant and characterist...
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Chapter
Effects of Piretanide on Sodium and Potassium Excretion and on Renal Hemodynamics
The efficacy of 6mg piretanide given orally on Na and K+ excretion as well as on renal hemodynamics was studied in 14 patients, with a GFR (Inulin-Clearance) ranging from 140 to 2 ml/min. Piretanide induced a nat...
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Article
Comparative enantioselective pharmacokinetic studies of celiprolol in healthy volunteers and patients with impaired renal function
The pharmacokinetics of the ß1-selective adrenergic antagonist (R,S)-celiprolol has been studied after oral administration of 200 mg celiprolol-HCl to 8 healthy volunteers and 8 patients with various degrees of i...
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Article
Saluretic effect of the loop diuretic torasemide in chronic renal failure
The effects of torasemide have been studied in 7 healthy controls and 9 patients with stable chronic renal failure of various degrees.
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Article
Pharmacokinetics of torasemide and its metabolites in healthy controls and in chronic renal failure
The pharmacokinetics of 20 mg torasemide i.v. has been studied in 7 healthy controls and 9 patients with varying degrees of renal impairment.
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Article
Gemfibrozil absorption and elimination in kidney and liver disease
The disposition of the lipid-lowering drug gemfibrozil was studied in patients with either renal (n= 8) or hepatic disease (n= 8) and compared to those of healthy volunteers (n= 6). Gemfibrozil was determined in ...
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Article
Prediction of diuretic mobilization of cirrhotic ascites by pretreatment fractional sodium excretion
In a randomized prospective study the efficacy and side effects of xipamide versus the combination spironolactone/furosemide in the treatment of cirrhotic ascites were studied. Out of 27 patients four responde...
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Article
Single- and multiple-dose pharmacokinetics of R-(−)- and S-(+)-prenylamine in man
The pharmacokinetics of S-(+)- and R-(−)-prenylamine was studied in eight healthy volunteers given single and repeated oral doses of the racemic drug.
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Chapter and Conference Paper
Diuretikatherapie im Alter
Diuretika gehören nicht nur zu den für die Behandlung von Herz-Kreislauf-Erkrankungen bedeutsamen Arzneistoffgruppen, sondern auch zu den am häufigsten bei alten Menschen eingesetzten Medikamenten. Etwa 50–60%...
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Chapter and Conference Paper
Diuretika und Vasodilatantien bei Herzinsuffizienz
Die zunächst nützlichen Mechanismen zur Kompensation einer Herzinsuffizienz können derartig gesteigert sein, daß sie ihrerseits zum wesentlichen Faktor für die Manifestation der Herzinsuffizienz werden. Diese ...
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Article
Pharmacokinetics of amiloride in renal and hepatic disease
The pharmacokinetics of the antikaliuretic amiloride has been studied in healthy controls and in patients with chronic renal failure or hepatitis. It was 40% bound to protein.
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Chapter
Pharmacodynamics and kinetics of torasemide and its metabolites in chronic renal failure after i.v. administration of 20 mg torasemide
Torasemide is a new loop diuretic with a similar pharmacodynamic action as furosemide. In contrast to furosemide, which is predominantly excreted unchanged, torasemide undergoes extensive oxidative biotransfor...
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Article
Modelling of colonic Cl− and K+ transport under resting and secreting conditions
Transport of electrolytes, particularly of Cl− and K+, by the rat proximal colon was studied in vivo under conditions of high and low K+ diet and in the presence of transport inhibitors and secretagogues. The ele...
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Chapter and Conference Paper
Neuere Aspekte der Pharmakokinetik von Diuretika
Seit vor weniger als 30 Jahren das erste oral wirksame Diuretikum in die Therapie eingeführt worden ist, hat die Wirkstoffgruppe der Diuretika immer mehr an Bedeutung gewonnen. Zahlreiche Substanzen mit unters...
