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Chapter
Immuunziekten en allergie
Het immuunsysteem heeft zich in de evolutie ontwikkeld als een afweersysteem tegen infectieuze agentia. Individuen met een deficiënt immuunsysteem bezwijken aan infecties als ze niet behandeld worden; er bestaat ...
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Article
L’ipotiroxinemia e la positività degli anticorpi anti-tireoperossidasi durante la gestazione rappresentano fattori di rischio per il parto prematuro: risultati dello studio Generation R
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Article
Open AccessMast cells are major contributors to the pathophysiology of Graves’ Ophthalmopathy (GO)
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Article
Open AccessEfficacy of adalimumab in sarcoidosis
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Article
Funzione tiroidea materna nella prima fase della gravidanza e funzioni cognitiva nella prima infanzia: lo studio “Generazione R”
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Chapter
T-γδ Receptor Restriction in Peripheral Lymphocytes of Patients with Behçet’s Disease
We found high numbers of Vδ T cells in 8 patients with Behçet’s disease. The role of this T cell receptor repertoire in Behçet’s disease is unknown and is subject of further investigation.
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Article
Regeneration pattern of precursor-B-cells in bone marrow of acute lymphoblastic leukemia patients depends on the type of preceding chemotherapy
Immunofluorescence stainings for the CD10 antigen and terminal deoxynucleotidyl transferase (TdT) can be used for the detection of leukemic blasts in CD10+ precursor-B-acute lymphoblastic leukemia (precursor-B-AL...
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Article
Flow cytometric detection of intracellular antigens for immunophenoty** of normal and malignant leukocytes: testing of a new fixation-permeabilization solution
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Article
Heterogeneity in junctional regions of immunoglobulin kappa deleting element rearrangements in B cell leukemias: a new molecular target for detection of minimal residual disease
Virtually all immunoglobulin kappa (IGK) gene deletions are mediated via rearrangements of the so-called kappa deleting element (Kde). Kde rearrangements occur either to Vκ gene segments (Vκ–Kde rearrangements) o...
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Article
Systemic and anti-neuronal auto-antibodies in patients with paraneoplastic neurological disease
Sera from 23 patients with paraneoplastic disease of the central nervous system (PNS) were examined for the presence of anti-neuronal (anti-Hu, anti-Yo/PCA) and anti-Ri) and systemic auto-antibodies, including...
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Chapter and Conference Paper
Molecular Biology of Acute Lymphoblastic Leukemia: Implications for Detection of Minimal Residual Disease
Acute lymphoblastic leukemias (ALL) are characterized by high frequencies of clonal chromosome aberrations (ploidy aberrations and translocations) as well as by clonal rearrangements of immunoglobulin (Ig) and...
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Chapter and Conference Paper
Immunophenotypic and Immunogenotypic Detection of Minimal Residual Disease in Acute Lymphoblastic Leukemia
Despite major improvements in the treatment of patients with acute lymphoblastic leukemia’s (ALL) during the last two decades, still 20%–30% of children with ALL and 60%-75% of adult ALL patients will develop ...
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Chapter and Conference Paper
Double Marker Analysis for Terminal Deoxynucleotidyl Transferase and Myeloid Antigens in Acute Nonlymphocytic Leukemia Patients and Healthy Subjects
The enzyme terminal deoxynucleotidyl transferase (TdT) is expressed on the nuclear membrane of normal precursor B and T cells as well as their malignant counterparts, i.e., acute lymphoblastic leukemias (ALLs)...
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Chapter
Immunological marker analysis of cells in the various hematopoietic differentiation stages and their malignant counterparts.
The characterization of cells in the various hematopoietic differentiation stages can be performed morphologically. Additional characterization is obtained by immunological marker analysis (1–4). The expressio...
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Chapter
Detection of Minimal Residual Acute Lymphoblastic Leukemia by Immunological Marker Analysis: Possibilities and Limitations
The detection of small numbers of malignant cells is a major problem at diagnosis and during follow-up of malignancies (1). The possibilities and limitations of methods for the detection of minimal residual di...
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Chapter
The Small Subpopulation of T Cell Marker+/Tdt+ Cells in the Human Bone Marrow may Represent Prothymocytes
Most normal haematopoietic differentiation stages have malignant counterparts in the form of a leukaemia or non-Hodgkin lymphoma (NHL) (Foon et al., 1982). The acute lymphoblastic leukaemias (ALL) may be regar...
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Article
Confirmation of the assignment of the gene coding for the BA-2 antigen to human chromosome 12
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Chapter
Detection of Minimal Residual Disease in TdT Positive T Cell Malignancies by Double Immunofluorescence Staining
Identification of small numbers of residual malignant cells is one of the major goals in cancer research. Detection of minimal disease enables better staging of the malignant process and provides information a...
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Article
Clones of helper T cells mediate antigen-specific, H–2-restricted DTH
It is now well established that in the mouse, helper T cells and killer T cells are two distinct thymus-derived lymphocyte sub-populations, differing from each other in Lyt phenotype and H–2 restriction, among...
