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Article
Rational pharmacotherapy of gastrointestinal motility disorders
Nervous control of gastrointestinal motility is extremely complex, is regulated by the enteric system, the “brain of the gut”, and modulated by extrinsic nerves. This system with its multiplicity of transmitte...
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Article
Effect of glucagon on adenylate cyclase activity and acid production of isolated human parietal cells
The direct effect of glucagon on human parietal cell function in vitro was tested by measuring adenylate cyclase (AC) activity and H+ production in homogenates of human gastric mucosa obtained during surgery or a...
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Article
Isolierte menschliche Magenschleimhautzellen — Untersuchungen physiologischer und pharmakologischer Regulationsmechanismen
Cells were isolated by use of collagenase, EDTA and pronase form human gastric mucosa obtained at peptic ulcer surgery (n=61) or at Whipple's operations (n=6). Enriched parietal cell fractions were prepared by is...
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Article
Cyclic GMP and acid production in isolated gastric cells of the rat
Just as cAMP is regarded as an intracellular mediator of histamine, so has cGMP been connected with cholinergic stimulation of gastric acid secretion. The object of the present investigation was to study the p...
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Article
Histamine content and release of isolated rat gastric mucosal cells
Enzymatically dispersed rat gastric cells were subdivided (Percoll®) in fractions (F1, F2, F3) with different number of parietal cells (PC) and the intracellular histamine content was estimated (ng/106 cells): F1...
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Article
Potentiating action of hexoprenaline on14C-aminopyrine uptake by isolated rat parietal cells
Hexoprenaline potentiated the14C-aminopyrine uptake (a reliable index of H+ generation) of isolated rat gastric cells stimulated by 10−6–10−4 mol/l carbachol, and inhibited that in response to 10−4 mol/l histamin...
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Article
Intrinsic factor secretion from isolated gastric mucosal cells of rat and man — two different patterns of secretagogue control
Intrinsic Factor (IF) secretion was studied using isolated gastric mucosal cells from rat and man. In the rat, IF was localized to the chief cells and its secretion responded most efficaciously to carbachol. D...
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Article
Comparison of the effect of PGE2 and somatostatin on histamine stimulated14C-aminopyrine uptake and cyclic AMP formation in isolated rat gastric mucosal cells
In isolated rat gastric cells somatostatin and PGE2 were compared in respect to their effects on the cAMP system and on the histamine-stimulated H+-production, measured by14C-aminopyrine (14C-AP) uptake. Like PGE
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Chapter and Conference Paper
Gastroenterologie
Nach Oberbauchoperationen wird zur Verhütung einer postoperativen Magenatonie häufig für einige Tage eine Magensonde gelegt. Die klinische Erfahrung zeigt, daß es nach längerer Liegezeit einer Magensonde zur E...
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Article
Adrenergic stimulation of isolated rat gastric mucosal cells
Adrenergic stimulation of the adenylate cyclase (AC)-cAMP-system and 14C-aminopyrine accumulation, an indirect measure of parietal cell H+-production, was studied in different preparations of gastric mucosal cell...
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Article
Histamine-sensitive adenylate cyclase in human gastric mucosa: Cellular localization and interaction by PGE2, somatostatin and secretin
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Article
Cyclic AMP in pancreatic and biliary secretion of children with chronic intrahepatic cholestasis and cystic fibrosis
The intracellular transmitter cAMP enters the extracellular space and can be found in the duodenal fluid. The role of this messenger was investigated in response to secretin and CCK in children with secretory ...
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Article
Pentagastrin activation of adenylate cyclase in human gastric biopsy specimens
Adenylate cyclase activity of human fundic mucosa is log-normally distributed and equally stimulated by pentagastrin and histamine. Cimetidine inhibits the histamine, but not the pentagastrin effect, which is ...
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Article
Human gastric mucosal adenylate cyclase: Activation by histamine-H2-receptor stimulation and inhibition by cimetidine in vitro and in peptic ulcer patients
Biopsy specimens of human fundic mucosa from 96 subjects were assayed for adenylate cyclase activity to characterize specificity of the histamine receptor with selective agonists and antagonists in vitro, and ...
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Chapter
Adenylate Cyclase and Specificity of the Histamine H2-Receptor in the Gastric Mucosa of the Guinea-Pig
Experimental data indicate that the histamine activated gastric mucosal adenylate cyclase (AC) of the guinea-pig is inhibited by histamine H1 and H2-receptor antagonists and the question raises whether the activa...
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Article
Cyclic AMP and cyclic GMP in the rat gastric mucosa
The investigation of the concentration of cAMP in vivo in the rat gastric mucosa, in relation to its function in gastric secretion, is complicated since the mucosa is not freely accessible.
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Article
Adenylate cyclase of the dog gastric mucosa: Stimulation by histamine and inhibition by metiamide
The activity of the non-stimulated, basal adenylate cyclase of the dog gastric mucosa is reduced by the histamine H2-receptor antagonist metiamide but not by the histamine H1-receptor antagonist mepyramine. Hista...
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Article
Adenylate cyclase and phosphodiesterase in the rat gastric mucosa after starvation, feeding and pentagastrin
The effects of starvation, feeding and pentagastrin on gastric mucosal adenylate cyclase (AC) and phosphodiesterase (PDE) activity were studied in the rat.
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Article
Do chickens have gastrin-like compounds?
Bei Hühnern wurden in Extrakten der Schleimhaut des Duodenums geringe Mengen einer Substanz nachgewiesen, die radioimmunologisch mit Antikörpern gegen synthetisches Humangastrin 2–17 reagiert. Serum, Oesophagu...
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Article
Hemmung der Magensaftsekretion von Hühnern durch Atropin, Insulin und 2-Desoxy-D-Glucose
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In unanaesthetized gastric fistula chickens the effect on gastric acid secretion was studied of atropine, ins...
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