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Article
Open AccessClonal hematopoiesis related TET2 loss-of-function impedes IL1β-mediated epigenetic reprogramming in hematopoietic stem and progenitor cells
Clonal hematopoiesis (CH) is defined as a single hematopoietic stem/progenitor cell (HSPC) gaining selective advantage over a broader range of HSPCs. When linked to somatic mutations in myeloid malignancy-asso...
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Article
The effect of polychlorinated biphenyls extracted from offshore sediments on the intestinal epithelium and microflora of zebrafish
Polychlorinated biphenyls are widespread, especially in the marine environment, where they may accumulate in several creatures in the food chain, contaminating fishmeal and seafood as well as posing a health h...
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Article
Untangling the Complex Interplay between Social Isolation, Anorexia, Sarcopenia, and Mortality: Insights from a Longitudinal Study
Social isolation is a pervasive and debilitating condition that has adverse prognostic impacts. This condition often co-occurs with other geriatric syndromes, further exacerbating negative health outcomes. Giv...
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Article
Xuebi**g injection treatment inhibits vasopermeability and reduces fluid requirements in a canine burn model
High vasopermeability and excessive inflammation following severe burns may result in tissue edema, organ dysfunction and the loss of circulatory plasma volume, which can influence the doctor to do the prognos...
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Article
MiR-181b modulates EGFR-dependent VCAM-1 expression and monocyte adhesion in glioblastoma
Tumor-associated macrophages (TAMs) originate as circulating monocytes, and are recruited to gliomas, where they facilitate tumor growth and migration. Understanding the interaction between TAM and cancer cell...
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Article
Inhibition of cyclooxygenase-2-mediated matriptase activation contributes to the suppression of prostate cancer cell motility and metastasis
Chronic inflammation plays an important role in cancer development and progression. Cyclooxygenases-2 (COX-2) is a key enzyme in generating prostaglandins causing inflammation, is often found to be overexpress...
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Article
MTCA.4-based LLRF control system for the C-ADS proton Linac injector I
The Chinese ADS proton Linac injector I composed of an electron cyclotron resonance ion source, a low-energy beam transport line, a radio frequency quadrupole (RFQ) accelerator, a medium-energy beam transport ...
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Article
Open AccessThe zinc-finger transcriptional factor Slug transcriptionally downregulates ERα by recruiting lysine-specific demethylase 1 in human breast cancer
Estrogen receptor α (ERα) is related with epithelial–mesenchymal transition, invasion and metastasis, and serves as an important therapeutic predictor and prognostic factor in breast cancer patients. The tripl...
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Article
Development of Transparent Electrodynamic Screens on Ultrathin Flexible Glass Film Substrates for Retrofitting Solar Panels and Mirrors for Self-Cleaning Function
Development of transparent electrodynamic screens (EDS) printed on ultrathin flexible glass film substrates for retrofitting on solar panels and solar mirrors to perform self cleaning function is reviewed. Lar...
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Article
The application of the cluster identification method for the detection of leakages in water distribution networks
To reduce the amount of water wastage caused by leakage, the utilities have to monitor and detect leakage of water distribution networks periodically. In order to identify leaking pipelines efficiently when li...
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Article
Mediating effects of social support and self-concept on depressive symptoms in adults with spinal cord injury
Cross-sectional, correlational design.
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Article
Open AccessThe relationship of TP53 R72P polymorphism to disease outcome and TP53 mutation in myelodysplastic syndromes
Nonsynonymous TP53 exon 4 single-nucleotide polymorphism (SNP), R72P, is linked to cancer and mutagen susceptibility. R72P associations with specific cancer risk, particularly hematological malignancies, have bee...
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Article
Open AccessCellular and Kaposi’s sarcoma-associated herpes virus microRNAs in sepsis and surgical trauma
Once a patient is in septic shock, survival rates drop by 7.6% for every hour of delay in antibiotic therapy. Biomarkers based on the molecular mechanism of sepsis are important for timely diagnosis and triage...
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Article
Sentinel node biopsy in papillary thyroid cancer—what is the potential?
Sentinel node biopsy (SNB) may identify lymph node metastases in patients with papillary thyroid cancer (PTC), enabling selective application of central node dissection (CND). The aim of this study was to asse...
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Article
Evidence of a role for CD44 and cell adhesion in mediating resistance to lenalidomide in multiple myeloma: therapeutic implications
Resistance of myeloma to lenalidomide is an emerging clinical problem, and though it has been associated in part with activation of Wnt/β-catenin signaling, the mediators of this phenotype remained undefined. ...
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Article
Open AccessRole of IGF2BP3 in trophoblast cell invasion and migration
The insulin-like growth factor-2 mRNA-binding protein 3 (IGF2BP3) is a member of a highly conserved protein family that is expressed specifically in placenta, testis and various cancers, but is hardly detectab...
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Article
Open AccessSTAT3 upregulates miR-92a to inhibit RECK expression and to promote invasiveness of lung cancer cells
Signal transducer and activator of transcription 3 (STAT3) activation is frequently found in human lung cancer and is associated with increased metastasis and reduced survival. How STAT3 enhances invasiveness ...
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Article
Open AccessThe proprotein convertase furin is required for trophoblast syncytialization
The multinucleated syncytial trophoblast, which forms the outermost layer of the placenta and serves multiple functions, is differentiated from and maintained by cytotrophoblast cell fusion. Deficiencies in sy...
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Article
Open AccessCUL1 promotes trophoblast cell invasion at the maternal–fetal interface
Human trophoblast progenitor cells differentiate via two distinct pathways, to become the highly invasive extravillous cytotrophoblast (CTB) cells (EVT) or fuse to form syncytiotrophoblast. Inadequate trophobl...
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Article
Open AccessSuppressor of cytokine signaling 6 (SOCS6) promotes mitochondrial fission via regulating DRP1 translocation
Mitochondria are highly motile organelles that constantly undergo fission and fusion. Impairment of mitochondrial dynamics is associated with mitochondrial dysfunction and is frequently linked to the pathogene...
