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Article
Open AccessThe Arkadia-ESRP2 axis suppresses tumor progression: analyses in clear-cell renal cell carcinoma
Tumor-specific alternative splicing is implicated in the progression of cancer, including clear-cell renal cell carcinoma (ccRCC). Using ccRCC RNA sequencing data from The Cancer Genome Atlas, we found that ep...
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Article
Open AccessDe novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy
Enhanced lipid biosynthesis is a characteristic feature of cancer. Deregulated lipogenesis plays an important role in tumour cell survival. These observations suggest that enzymes in the lipid synthesis pathwa...
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Article
Targeting Tankyrase 1 as a therapeutic strategy for BRCA-associated cancer
The BRCA1 and BRCA2 proteins are involved in the maintenance of genome stability and germ-line loss-of-function mutations in either BRCA1 or BRCA2 strongly predispose carriers to cancers of the breast and other o...
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Article
Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions
Extracellular acidosis (low pH) is a tumor microenvironmental stressor that has a critical function in the malignant progression and metastatic dissemination of tumors. To survive under stress conditions, tumo...
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Article
G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3′ telomeric overhang in cancer cells
Inhibition of telomerase activity by telomerase inhibitors induces a gradual loss of telomeres, and this in turn causes cancer cells to enter to a crisis stage. Here, we report the telomerase inhibitor telomes...
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Article
Open AccessThe telomeric PARP, tankyrases, as targets for cancer therapy
The requirement for the maintenance of telomeres by telomerase by most cancer cells for continued proliferation is a target in anticancer strategies. Tankyrases are poly(ADP-ribose) polymerases that enhance te...
