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within H Seimiya Remove this filter Internal Medicine Remove this filter Oncology Remove this filter

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  1. Article

    Open Access

    The Arkadia-ESRP2 axis suppresses tumor progression: analyses in clear-cell renal cell carcinoma

    Tumor-specific alternative splicing is implicated in the progression of cancer, including clear-cell renal cell carcinoma (ccRCC). Using ccRCC RNA sequencing data from The Cancer Genome Atlas, we found that ep...

    A Mizutani, D Koinuma, H Seimiya, K Miyazono in Oncogene (2016)

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  2. No Access

    Article

    Targeting Tankyrase 1 as a therapeutic strategy for BRCA-associated cancer

    The BRCA1 and BRCA2 proteins are involved in the maintenance of genome stability and germ-line loss-of-function mutations in either BRCA1 or BRCA2 strongly predispose carriers to cancers of the breast and other o...

    N McCabe, M A Cerone, T Ohishi, H Seimiya, C J Lord, A Ashworth in Oncogene (2009)

  3. No Access

    Article

    Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions

    Extracellular acidosis (low pH) is a tumor microenvironmental stressor that has a critical function in the malignant progression and metastatic dissemination of tumors. To survive under stress conditions, tumo...

    T Mashima, S Sato, Y Sugimoto, T Tsuruo, H Seimiya in Oncogene (2009)

  4. No Access

    Article

    G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3′ telomeric overhang in cancer cells

    Inhibition of telomerase activity by telomerase inhibitors induces a gradual loss of telomeres, and this in turn causes cancer cells to enter to a crisis stage. Here, we report the telomerase inhibitor telomes...

    H Tahara, K Shin-ya, H Seimiya, H Yamada, T Tsuruo, T Ide in Oncogene (2006)