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Life Sciences
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Article
Combined Analysis of Transcriptome and Small RNA Sequencing Reveals the Mechanism of UV-B-promoted Flavonoid Biosynthesis in Ginkgo biloba
Flavonoids are the most abundant medicinal ingredients in Ginkgo biloba L. leaf extract (GBE), which is an important industrial raw material for the treatment of cardiovascular and cerebrovascular diseases. Our p...
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Enhancer selectivity in space and time: from enhancer–promoter interactions to promoter activation
The primary regulators of metazoan gene expression are enhancers, originally functionally defined as DNA sequences that can activate transcription at promoters in an orientation-independent and distance-indepe...
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Mechanism of Melatonin Promotion of Flavonoid Biosynthesis in Ginkgo biloba
Ginkgo biloba leaves are rich in flavonoids and have significant medicinal value. Exogenous hormones can affect flavonoids biosynthesis, but as a novel hormone, the effect of melatonin on G. biloba flavonoids bio...
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Open AccessTargeting miR-181a/b in retinitis pigmentosa: implications for disease progression and therapy
Retinitis pigmentosa (RP) is a genetically heterogeneous group of degenerative disorders causing progressive vision loss due to photoreceptor death. RP affects other retinal cells, including the retinal pigmen...
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SMURF1-Interference Effects Autophagy and Pulmonary Fibrosis through SMAD7 and the TGF-β1/SMAD Pathway
SMAD-specific E3 ubiquitin proten ligase 1 (SMURF1) is involved in transforming growth factor (TGF)-β1/Smad pathway-mediated tissue fibrosis. However, its role in pulmonary fibrosis and the related molecular m...
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Open AccessLipid profiles of plants and soil microbial communities are shaped by soil parent material in Australian sclerophyll forests
Plant and soil microbes can reduce their phosphorus (P)-requirements by replacing phospholipids with non-P containing lipids (e.g., galactolipids, sulfolipids, and betaine lipids). There have been few studies ...
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Open AccessSingle-cell T-cell receptor repertoire profiling in dogs
Spontaneous cancers in companion dogs are robust models of human disease. Tracking tumor-specific immune responses in these models requires reagents to perform species-specific single cell T cell receptor sequ...
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The Relationship Between Systemic Lupus Erythematosus and Osteoporosis Based on Different Ethnic Groups: a Two-Sample Mendelian Randomization Analysis
The previous observational studies could not overcome the effects of confounding variables and reverse causality. We aimed to determine whether there is a causal relationship between systemic lupus erythematos...
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Open AccessSoil microbial community response to ectomycorrhizal dominance in diverse neotropical montane forests
Ectomycorrhizal (EM) associations can promote the dominance of tree species in otherwise diverse tropical forests. These EM associations between trees and their fungal mutualists have important consequences fo...
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Improving growth, omega-3 contents, and disease resistance of Asian seabass: status of a 20-year family-based breeding program
Aquaculture has been one of the fastest-growing sectors in agriculture and plays an important role in supplying high quality proteins for humans. Genetic improvement for important traits is essential for incre...
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Bacterial genome engineering using CRISPR-associated transposases
Clustered regularly interspaced short palindromic repeats (CRISPR)-associated transposases have the potential to transform the technology landscape for kilobase-scale genome engineering, by virtue of their abi...
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Open AccessCorrection: Mesenchymal stem cells transplantation for perianal fistulas: a systematic review and meta-analysis of clinical trials
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Phenotypic Plasticity of Two Stipa in Grassland Responses to Elevated CO2 and Precipitation Change
Elevated atmospheric CO2 concentration and precipitation change affect plants’ survival and thriving. Phenotypic plasticity can show plants adaptability to varying environment. Physiological plasticity reflects p...
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The Development of SpCas9 Variants with High Specificity and Efficiency Based on the HH Theory
Streptococcus pyogenes Cas9 (SpCas9) is the most popular tool in gene editing; however, off-target mutagenesis is one of the biggest impediments in its application. In our previous study, we proposed the HH theor...
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High-throughput transcriptomics of 409 bacteria–drug pairs reveals drivers of gut microbiota perturbation
Many drugs can perturb the gut microbiome, potentially leading to negative health consequences. However, mechanisms of most microorganism–drug responses have not been elucidated at the genetic level. Using hig...
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Root exudation links root traits to soil functioning in agroecosystems
Root exudation is a key process for plant nutrient acquisition, but the controls on root exudation and its relationship to soil C and N processes in agroecosystems are unclear. We hypothesized that root exudat...
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Biosynthesis of eriodictyol in citrus waster by endowing P450BM3 activity of naringenin hydroxylation
The flavonoid naringenin is abundantly present in pomelo peels, and the unprocessed naringenin in wastes is not friendly for the environment once discarded directly. Fortunately, the hydroxylated product of er...
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Isopod mouthpart traits respond to a tropical forest recovery gradient
Functional trait ecology has the potential to provide generalizable and mechanistic predictions of ecosystem function from data of species distributions and traits. The traits that are selected should both res...
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Erratum to: Effects of Chlormequat Chloride and Paclobutrazol on the Growth and Chlorophyll Fluorescence Kinetics of Daphne genkwa
An Erratum to this paper has been published: https://doi.org/10.1134/S1021443723900016
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Low-depth Raw Reads of Nanopore Sequencing Enables Rapid and Accurate Bacterial Identification
The recent advent of third-generation sequencing technologies brings promise for better bacterial identification. However, the commercial applications of the current sequencing technologies are still constrain...
