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Article
Open AccessSIRT1 ISGylation accelerates tumor progression by unleashing SIRT1 from the inactive state to promote its deacetylase activity
ISG15 is an interferon-stimulated ubiquitin-like protein (UBL) with multifaceted roles as a posttranslational modifier in ISG15 conjugation (ISGylation). However, the mechanistic consequences of ISGylation in ...
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Article
Open AccessNovel aminopyridazine derivative of minaprine modified by radiolysis presents potent anti-inflammatory effects in LPS-stimulated RAW 264.7 and DH82 macrophage cells
Radiation molecularly transforms naturally occurring products by inducing the methoxylation, hydroxylation, and alkylation of parent compounds, thereby affecting the anti-inflammatory capacities of those compo...
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Article
Open AccessA comparative study on the implementation of deep learning algorithms for detection of hepatic necrosis in toxicity studies
Deep learning has recently become one of the most popular methods of image analysis. In non-clinical studies, several tissue slides are generated to investigate the toxicity of a test compound. These are conve...
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Article
Open AccessSegmentation algorithm can be used for detecting hepatic fibrosis in SD rat
Liver fibrosis is an early stage of liver cirrhosis. As a reversible lesion before cirrhosis, liver failure, and liver cancer, it has been a target for drug discovery. Many antifibrotic candidates have shown p...
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Article
Open AccessPreparing pathological data to develop an artificial intelligence model in the nonclinical study
Artificial intelligence (AI)-based analysis has recently been adopted in the examination of histological slides via the digitization of glass slides using a digital scanner. In this study, we examined the effe...
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Article
Open AccessMechanism of (−)-epigallocatechin gallate (EGCG) dimerization by low-temperature plasma
The efficient dimerization of (−)-Epigallocatechin gallate (EGCG), which is the major bioactive constituent isolated from the leaves of Camellia sinensis, was initially reported without changes in its stereochemi...
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Article
Open AccessThe effect of the multimodal intervention including an automatic notification of catheter days on reducing central line-related bloodstream infection: a retrospective, observational, quasi-experimental study
A central venous catheter (CVC) is an important medical device, but it could be preceding infection and the risk of central line-associated bloodstream infection (CLABSI). CLABSI is a common healthcare-associa...
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Article
Author Correction: Layer-controlled single-crystalline graphene film with stacking order via Cu–Si alloy formation
A Correction to this paper has been published: https://doi.org/10.1038/s41565-020-00821-z.
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Article
Open AccessSelf-selective van der Waals heterostructures for large scale memory array
The large-scale crossbar array is a promising architecture for hardware-amenable energy efficient three-dimensional memory and neuromorphic computing systems. While accessing a memory cell with negligible snea...
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Article
Open AccessStructural homogeneity and mass density of bulk metallic glasses revealed by their rough surfaces and ultra-small angle neutron scattering (USANS)
The ultra-small angle neutron scattering (USANS) measures the microscale structure of heterogeneity and the scattering from rough surfaces with small scattering volumes can be neglected. But this is not true i...
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Article
Open AccessMolecular detection of Anaplasma bovis in Holstein cattle in the Republic of Korea
Anaplasmosis is a tick-borne infectious disease that affects both human and animal health. This study was performed to characterize and investigate the prevalence of infection with Anaplasma bovis in Holstein cat...
