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Article
Neurotensin orchestrates valence assignment in the amygdala
The ability to associate temporally segregated information and assign positive or negative valence to environmental cues is paramount for survival. Studies have shown that different projections from the basola...
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Article
Nontoxic, double-deletion-mutant rabies viral vectors for retrograde targeting of projection neurons
Recombinant rabies viral vectors have proven useful for applications including retrograde targeting of projection neurons and monosynaptic tracing, but their cytotoxicity has limited their use to short-term ex...
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Article
Architectural Representation of Valence in the Limbic System
In order to thrive, animals must be able to recognize aversive and appetitive stimuli within the environment and subsequently initiate appropriate behavioral responses. This assignment of positive or negative ...
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Article
Resolving the neural circuits of anxiety
A mechanistic understanding of anxiety is required to advance the development of next-generation therapies for anxiety disorders. In this Review, Calhoon and Tye discuss recent insights into the circuit physio...
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Article
A circuit mechanism for differentiating positive and negative associations
Neurons in the basolateral amygdala projecting to canonical fear or reward circuits undergo opposing changes in synaptic strength following fear or reward conditioning, and selectively activating these project...
