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Open AccessFunctional analysis of the Aspergillus fumigatus kinome identifies a druggable DYRK kinase that regulates septal plugging
More than 10 million people suffer from lung diseases caused by the pathogenic fungus Aspergillus fumigatus. Azole antifungals represent first-line therapeutics for most of these infections but resistance is risi...
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Open AccessSirtuin E deacetylase is required for full virulence of Aspergillus fumigatus
Aspergillus fumigatus represents a public health problem due to the high mortality rate in immunosuppressed patients and the emergence of antifungal-resistant isolates. Protein acetylation is a crucial post-trans...
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Open AccessAn oxylipin signal confers protection against antifungal echinocandins in pathogenic aspergilli
Aspergillus fumigatus is the leading causative agent of life-threatening invasive aspergillosis in immunocompromised individuals. One antifungal class used to treat Aspergillus infections is the fungistatic echin...
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Open AccessAspergillus fumigatus mitogen-activated protein kinase MpkA is involved in gliotoxin production and self-protection
Aspergillus fumigatus is a saprophytic fungus that can cause a variety of human diseases known as aspergillosis. Mycotoxin gliotoxin (GT) production is important for its virulence and must be tightly regulated to...
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Open AccessA host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi
Fungal infections cause more than 1.5 million deaths a year. Due to emerging antifungal drug resistance, novel strategies are urgently needed to combat life-threatening fungal diseases. Here, we identify the h...
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COVID-19-associated fungal infections
Coronavirus disease 2019 (COVID-19)-associated invasive fungal infections are an important complication in a substantial number of critically ill, hospitalized patients with COVID-19. Three groups of fungal pa...
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Nutritional factors modulating plant and fruit susceptibility to pathogens: BARD workshop, Haifa, Israel, February 25–26, 2018
The molecular dialog between fungal pathogens and their plant hosts is governed by signals from the plant, secreted pathogen effectors and enzymes, and the plant immune system. There is an increasing awareness...
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Open AccessCharacterization of a novel sugar transporter involved in sugarcane bagasse degradation in Trichoderma reesei
Trichoderma reesei is a saprophytic fungus implicated in the degradation of polysaccharides present in the cell wall of plants. T. reesei has been recognized as the most important industrial fungus that secretes ...
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Open AccessThe low affinity glucose transporter HxtB is also involved in glucose signalling and metabolism in Aspergillus nidulans
One of the drawbacks during second-generation biofuel production from plant lignocellulosic biomass is the accumulation of glucose, the preferred carbon source of microorganisms, which causes the repression of...
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Open AccessComparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus
The fungal genus Aspergillus is of critical importance to humankind. Species include those with industrial applications, important pathogens of humans, animals and crops, a source of potent carcinogenic contamina...
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Expression of Two Novel β-Glucosidases from Chaetomium atrobrunneum in Trichoderma reesei and Characterization of the Heterologous Protein Products
Two novel GH3 family thermostable β-glucosidases from the filamentous fungus Chaetomium atrobrunneum (CEL3a and CEL3b) were expressed in Trichoderma reesei, purified by two-step ion exchange chromatography, and c...
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Open AccessRNAseq reveals hydrophobins that are involved in the adaptation of Aspergillus nidulans to lignocellulose
Sugarcane is one of the world’s most profitable crops. Waste steam-exploded sugarcane bagasse (SEB) is a cheap, abundant, and renewable lignocellulosic feedstock for the next-generation biofuels. In nature, fu...
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The contribution of Aspergillus fumigatus stress responses to virulence and antifungal resistance
Invasive aspergillosis has emerged as one of the most common life-threatening fungal disease of humans. The emergence of antifungal resistant pathogens represents a current and increasing threat to society. In...
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Open AccessFetal microchimerism in kidney biopsies of lupus nephritis patients may be associated with a beneficial effect
Microchimeric male fetal cells (MFCs) have been associated with systemic lupus erythematosus, and published studies have further correlated MFC with lupus nephritis (LN). In the present study, we evaluated the...
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Open AccessComparative metabolism of cellulose, sophorose and glucose in Trichoderma reeseiusing high-throughput genomic and proteomic analyses
The filamentous fungus Trichoderma reesei is a major producer of lignocellulolytic enzymes utilized by bioethanol industries. However, to achieve low cost second generation bioethanol production on an industrial ...
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Open AccessTranscriptome analysis of Aspergillus niger grown on sugarcane bagasse
Considering that the costs of cellulases and hemicellulases contribute substantially to the price of bioethanol, new studies aimed at understanding and improving cellulase efficiency and productivity are of pa...
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Genetic Improvement of Xylose Utilization by Saccharomyces cerevisiae
It is estimated that capital costs associated with lignocellulosic ethanol are about US $4 per gallon and that these need to be reduced by more than half to be economically sustainable (Hahn-Hagerdal et al. 2...
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Open AccessIdentification of possible targets of the Aspergillus fumigatus CRZ1 homologue, CrzA
Calcineurin, a serine/threonine-specific protein phosphatase, plays an important role in the control of cell morphology and virulence in fungi. Calcineurin regulates localization and activity of a transcriptio...
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Open AccessA reliable measure of similarity based on dependency for short time series: an application to gene expression networks
Microarray techniques have become an important tool to the investigation of genetic relationships and the assignment of different phenotypes. Since microarrays are still very expensive, most of the experiments...
