21 Result(s)
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Article
Effects of Testosterone in Mediating the Relationship Between Daytime Nap** and Osteoporosis in European Populations: A Mendelian Randomization Study
We aimed to explore the causal effect of daytime nap** on the risk of osteoporosis and the mediation role of testosterone in explaining this relationship. Summary data for Mendelian randomization (MR) analys...
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Article
Recent advances of sesquiterpenoid dimers from Compositae: distribution, chemistry and biological activities
Composite family contains a wide variety of plants and many of them possess high medicinal value. Various constituents have been isolated from members of Composite family. Sesquiterpenoids prove to be the char...
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Article
Open AccessTFEB and TFE3 cooperate in regulating inorganic arsenic-induced autophagy-lysosome impairment and immuno-dysfunction in primary dendritic cells
Arsenic (As) is a prevalent and hazardous environmental toxicant associated with cancer and various health problems, which has been shown suppressive effects on dendritic cells (DCs). Autophagy is essential fo...
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Article
Open AccessBCL2L13 promotes mitophagy through DNM1L-mediated mitochondrial fission in glioblastoma
There is an urgent need for novel diagnostic and therapeutic strategies for patients with Glioblastoma multiforme (GBM). Previous studies have shown that BCL2 like 13 (BCL2L13) is a member of the BCL2 family r...
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Article
Open AccessThe CDK inhibitor AT7519 inhibits human glioblastoma cell growth by inducing apoptosis, pyroptosis and cell cycle arrest
Glioblastoma multiforme (GBM) is the most lethal primary brain tumor with a poor median survival of less than 15 months. However, clinical strategies and effective therapies are limited. Here, we found that th...
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Article
Open AccessPP6 negatively modulates LUBAC-mediated M1-ubiquitination of RIPK1 and c-FLIPL to promote TNFα-mediated cell death
Activation of TNFR1 by TNFα induces the formation of a membrane-associated, intracellular complex termed complex I. Complex I orchestrates a complex pattern of modifications on key regulators of TNF signaling ...
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Article
Open AccessCHBP induces stronger immunosuppressive CD127+ M-MDSC via erythropoietin receptor
Erythropoietin (EPO) is not only an erythropoiesis hormone but also an immune-regulatory cytokine. The receptors of EPO (EPOR)2 and tissue-protective receptor (TPR), mediate EPO’s immune regulation. Our group fir...
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Article
Open AccessASPP2 inhibits tumor growth by repressing the mevalonate pathway in hepatocellular carcinoma
Cancer is, fundamentally, a disorder of cell growth and proliferation, which requires adequate supplies of energy and nutrients. In this study, we report that the haplo-insufficient tumor suppressor ASPP2, a p...
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Article
Folic acid inhibits homocysteine-induced cell apoptosis in human umbilical vein endothelial cells
Homocysteine may be responsible for vascular endothelial cell injury, which occurs early in the pathology of cardiovascular disease. Homocysteine metabolism requires enzymatic interaction with vitamins such as...
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Article
Dityrosine administration induces dysfunction of insulin secretion accompanied by diminished thyroid hormones T3 function in pancreas of mice
Oxidized tyrosine products are commonly found in food with high protein content and have been demonstrated to cause damage of liver and kidney in our previous studies. Dityrosine (Dityr) is a typical oxidized ...
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Article
Dietary oxidized tyrosine (O-Tyr) stimulates TGF-β1-induced extracellular matrix production via the JNK/p38 signaling pathway in rat kidneys
Oxidized tyrosine (O-Tyr) products have been detected in commercial food and have been demonstrated to induce liver injury in our previous study, but the precise mechanisms of the impact induced by dietary O-T...
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Article
Identification of a novel endophytic fungus from Huperzia serrata which produces huperzine A
Huperzine A is isolated from Huperzia serrata and is used for treatment of Alzheimer’s disease, due to its low toxicity and long effective period. The decrease in H. serrata sources means that natural huperzine A...
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Article
Folic Acid Acts Through DNA Methyltransferases to Induce the Differentiation of Neural Stem Cells into Neurons
The present study investigated the roles of folic acid and DNA methyltransferases (DNMTs) in the differentiation of neural stem cells (NSCs). Neonatal rat NSCs were grown in suspended neurosphere cultures and ...
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Article
Human pathogenic fungus Trichophyton schoenleinii activates the NLRP3 inflammasome
The fungus Trichophyton schoenleinii (T. schoenleinii) is the causative agent of Trichophytosis and Tinea favosa of the scalp in certain regions of Eurasia and Africa. Human innate immune system plays an importan...
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Article
Effects of Homocysteine on ERK Signaling and Cell Proliferation in Fetal Neural Stem Cells In Vitro
The aim of the present study was to determine if the excitatory amino acid homocysteine (Hcy) alters ERK signaling and cell proliferation in fetal neural stem cells (NSCs) in vitro. NSCs were isolated from fet...
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Article
Seed size is determined by the combinations of the genes controlling different seed characteristics in rice
Rice seed size is an important agronomic trait in determining the yield potential, and four seed size related genes (GS3, GW2, qSW5/GW5 and GIF1) have been cloned in rice so far. However, the relationship among t...
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Article
Confined detection volume of fluorescence correlation spectroscopy by bare fiber probes
A fiber-tip-based near-field fluorescence correlation spectroscopy (FCS) has been developed for confining the detection volume to sub-diffraction-limited dimensions. This near-field FCS is based on near-field ...
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Article
Mechanism, function and regulation of microtubule-dependent microtubule amplification in mitosis
Mitotic spindle mediates the segregation of chromosomes in the cell cycle and the proper function of the spindle is crucial to the high fidelity of chromosome segregation and to the stability of the genome. Nu...
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Protocol
PCR-Mediated Recombination
Molecular cloning has proven to be a powerful tool in biology, and chimeric clones are useful in a variety of fields including microbial pathogenesis and the development of vaccines. Chimeras can be created fr...
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Article
Purification of plasmid DNA using a multicompartment electrolyser separated by ultrafilter membranes
A simple, scalable method for purification of plasmid DNA is described. Plasmid DNA was released from Escherichia coli JM109 by lysis (1% SDS, 0.2 M NaOH). Then a neutralization solution (3 M sodium acetate buffe...
