Abstract
Composite family contains a wide variety of plants and many of them possess high medicinal value. Various constituents have been isolated from members of Composite family. Sesquiterpenoids prove to be the characteristic constituents. In recent years, phytochemical studies on natural sesquiterpenoids, especially the sesquiterpenoid dimers from Composite have been a hot spot. As an important class of bioactive natural products, about 260 novel sesquiterpenoid dimers were isolated from plants of Compositae family since 2018 till date and most of them displayed significant therapeutic potential including anti-inflammatory, anti-tumor, neuroprotective, and other effects. In this review, the structural features, plant resources, and biological activities of these newly discovered sesquiterpenoid dimers were summarized.
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Bitchagno GTM, Schuffler A, Gross J, Krumb M, Tane P, Opatz T (2022) Sesquiterpene lactones from Vernonia tufnelliae: structural characterization and biological evaluation. J Nat Prod 85:1681–1690. https://doi.org/10.1021/acs.jnatprod.2c00055
Bitew H, Hymete A (2019) The genus Echinops: phytochemistry and biological activities: a review. Front Pharmacol 10:1234. https://doi.org/10.3389/fphar.2019.01234
Caprioglio D, Salamone S, Pollastro F, Minassi A (2021) Biomimetic approaches to the synthesis of natural disesquiterpenoids: an update. Plants. https://doi.org/10.3390/plants10040677
Cardenas DM, Mejias FJR, Molinillo JMG, Macias FA (2020) Synthesis of vlasouliolides: a pathway toward guaiane-eudesmane C17/C15 dimers by photochemical and Michael additions. J Org Chem 85:7322–7332. https://doi.org/10.1021/acs.joc.0c00705
Chen C, Ren YM, Zhu JZ, Chen JL, Feng ZL, Zhang T, Ye Y, Lin LG (2022) Ainsliadimer C, a disesquiterpenoid isolated from Ainsliaea macrocephala, ameliorates inflammatory responses in adipose tissue via Sirtuin 1-NLRP3 inflammasome axis. Acta Pharmacol Sin 43:1780–1792. https://doi.org/10.1038/s41401-021-00797-z
Committee of Flora of China (1985) Flora of China, vol 75. Science Press, Bei**g, p 1
Ding Y, Wang T, Chen T, **e C, Zhang Q (2020) Sesquiterpenoids isolated from the flower of Inula japonica as potential antitumor leads for intervention of paclitaxel-resistant non-small-cell lung cancer. Bioorg Chem 101:103973. https://doi.org/10.1016/j.bioorg.2020.103973
Ding N, Wang J, Liu J, Zhu Y, Hou S, Zhao H, Yang Y, Chen X, Hu L, Wang X (2021) Cytotoxic guaianolide sesquiterpenoids from Ainsliaea fragrans. J Nat Prod 84:2568–2574. https://doi.org/10.1021/acs.jnatprod.1c00587
Dong W, Li TZ, Huang XY, He XF, Geng CA, Zhang XM, Chen JJ (2022) Artemzhongdianolides A1–A21, antihepatic fibrosis guaiane-type sesquiterpenoid dimers from Artemisia zhongdianensis. Bioorg Chem 128:106056. https://doi.org/10.1016/j.bioorg.2022.106056
Dürr L, Reinhardt JK, Dobrzyński M, Hell T, Smiesko M, Pertz O, Hamburger M, Garo E (2022) A dimerosesquiterpene and sesquiterpene lactones from Artemisia argyi inhibiting oncogenic PI3K/AKT signaling in melanoma cells. J Nat Prod 85:2557–2569. https://doi.org/10.1021/acs.jnatprod.2c00471
Fraga BM (2011) Natural sesquiterpenoids. Nat Prod Rep 28:1580–1610. https://doi.org/10.1039/c1np00046b
Fraga BM (2012) Natural sesquiterpenoids. Nat Prod Rep 29:1334–1366. https://doi.org/10.1039/c2np20074k
Fraga BM (2013) Natural sesquiterpenoids. Nat Prod Rep 30:1226–1264. https://doi.org/10.1039/c3np70047j
Gao Z, Ma WJ, Li TZ, Ma YB, Hu J, Huang XY, Geng CA, He XF, Zhang XM, Chen JJ (2022) Artemidubolides A-T, cytotoxic unreported guaiane-type sesquiterpenoid dimers against three hepatoma cell lines from Artemisia dubia. Phytochemistry 202:113299. https://doi.org/10.1016/j.phytochem.2022.113299
Han JS, Kim JG, Le Linh TP, Cho YB, Lee D, Hong JT, Lee MK, Hwang BY (2023) Targeted isolation of sesquiterpene lactone dimers from Aucklandia lappa guided by LC-HRMS/MS-based molecular networking. Phytochemistry 206:113557. https://doi.org/10.1016/j.phytochem.2022.113557
He X, Li Q, Li T, Ma Y, Dong W, Yang K, Geng C, Zhang H, Wang Y, Chen J (2023a) Artemeriopolides A–D, two types of sesquiterpenoid dimers with rare carbon skeletons from Artemisia eriopoda and their antihepatoma cytotoxicity. Org Chem Front 10:2635–2641. https://doi.org/10.1039/d3qo00223c
He X, Ma W, Hu J, Li T, Geng C, Ma Y, Wang M, Yang K, Zhang X, Chen JJ (2023b) Diverse structures and antihepatoma effect of sesquiterpenoid dimers from Artemisia eriopoda by AKT/STAT signaling pathway. Signal Transduct Target Ther 8:64. https://doi.org/10.1038/s41392-022-01267-6
Jang Y, Han S (2020) Total synthesis of cinnamodial-based dimer (-)-capsicodendrin. J Org Chem 85:7576–7582. https://doi.org/10.1021/acs.joc.0c00740
** Q, Lee JW, Jang H, Lee HL, Kim JG, Wu W, Lee D, Kim EH, Kim Y, Hong JT, Lee MK, Hwang BY (2018) Dimeric- and trimeric sesquiterpenes from the flower of Inula japonica. Phytochemistry 155:107–113. https://doi.org/10.1016/j.phytochem.2018.07.008
Kim KC, Kim DJ, Lee MS, Seo JY, Yoo ID, Lee IS (2018) Inhibition of human neutrophil elastase by sesquiterpene lactone dimers from the flowers of Inula britannica. J Microbiol Biotechnol 27:1806–1813. https://doi.org/10.4014/jmb.1807.07039
Lai ST, Zhang T, Wang HQ, **e J, Liu JB, Chen RY, Kang J (2022) Two new sesquiterpene dimers isolated from the roots of Saussurea lappa (Yunmuxiang). J Asian Nat Prod Res 24:490–495. https://doi.org/10.1080/10286020.2021.2025049
Li H, Zheng Z, Wei W, Chen J, Gao K (2018) Ligusaginoids A–D, four eremophilane-type sesquiterpenoid dimers and trimers from Ligularia sagitta. Tetrahedron Lett 59:3461–3466. https://doi.org/10.1016/j.tetlet.2018.08.009
Liu T, Wu H, Jiang H, Zhang L, Zhang Y, Mao L (2019) Echingridimer A, an oxaspiro dimeric sesquiterpenoid with a 6/6/5/6/6 fused ring system from Echinops grijsii and aphicidal activity evaluation. J Org Chem 84:10757–10763. https://doi.org/10.1021/acs.joc.9b01212
Liu B, Fu S, Zhou C (2020) Naturally occurring [4 + 2] type terpenoid dimers: sources, bioactivities and total syntheses. Nat Prod Rep 37:1627–1660. https://doi.org/10.1039/c9np00037b
Liu Y, He Y, Wang F, Xu R, Yang M, Ci Z, Wu Z, Zhang D, Lin J (2021) From longevity grass to contemporary soft gold: explore the chemical constituents, pharmacology, and toxicology of Artemisia argyi H.Lev. & vaniot essential oil. J Ethnopharmacol 279:114404. https://doi.org/10.1016/j.jep.2021.114404
Luo P, Cheng Y, Yin Z, Li C, Xu J, Gu Q (2019) Monomeric and dimeric cytotoxic guaianolide-type sesquiterpenoids from the aerial parts of Chrysanthemum indicum. J Nat Prod 82:349–357. https://doi.org/10.1021/acs.jnatprod.8b00863
Luo J, Zhang D, Tang P, Wang N, Zhao S, Kong L (2023) Chemistry and bioactivity of lindenane sesquiterpenoids and their oligomers. Nat Prod Rep. https://doi.org/10.1039/d3np00022b
Ma LF, Chen YL, Shan WG, Zhan ZJ (2020a) Natural disesquiterpenoids: an update. Nat Prod Rep 37:999–1030. https://doi.org/10.1039/c9np00062c
Ma Y, Dou X, Tian X (2020b) Natural disesquiterpenoids: an overview of their chemical structures, pharmacological activities, and biosynthetic pathways. Phytochem Rev 19:983–1043. https://doi.org/10.1007/s11101-020-09698-1
Nadda RK, Ali A, Goyal RC, Khosla PK, Goyal R (2020) Aucklandia costus (Syn. Saussurea costus): ethnopharmacology of an endangered medicinal plant of the himalayan region. J Ethnopharmacol 263:113199. https://doi.org/10.1016/j.jep.2020.113199
Newman DJ, Cragg GM (2020) Natural products as sources of new drugs over the nearly four decades from 01/1981 to 09/2019. J Nat Prod 80:770–803. https://doi.org/10.1021/acs.jnatprod.9b01285
Nuermaimaiti M, Turak A, Yang Q, Tang B, Zang Y, Li J, Aisa HA (2021) Sesquiterpenes from Artemisia sieversiana and their anti-inflammatory activities. Fitoterapia 154:104996. https://doi.org/10.1016/j.fitote.2021.104996
Qin D, Pan D, **ao W, Li H, Yang B, Yao X, Dai Y, Yu Y, Yao X (2018) Dimeric cadinane sesquiterpenoid derivatives from Artemisia annua. Org Lett 20:453–456. https://doi.org/10.1021/acs.orglett.7b03796
Reinhardt JK, Klemd AM, Danton O, De Mieri M, Smiesko M, Huber R, Burgi T, Grundemann C, Hamburger M (2019) Sesquiterpene lactones from Artemisia argyi: absolute configuration and immunosuppressant activity. J Nat Prod 82:1424–1433. https://doi.org/10.1021/acs.jnatprod.8b00791
Ren Y, Zhou S, Zhang T, Qian M, Zhang R, Yao S, Zhu H, Tang C, Lin L, Ye Y (2020) Targeted isolation of two disesquiterpenoid macrocephadiolides A and B from Ainsliaea macrocephala using a molecular networking-based dereplication strategy. Org Chem Front 7:1481–1489. https://doi.org/10.1039/d0qo00030b
Shang C, Huang XY, Wang Y, Dong W, He XF, Li TZ, Chen JJ (2023) Artemongolides A–F, undescribed sesquiterpenoid dimers from Artemisia mongolica and their antihepatic fibrosis activities. Org Biomol Chem 21:823–831. https://doi.org/10.1039/d2ob02182j
Shao Y, Sun Y, Li D, Chen Y (2020) Chrysanthemum indicum L.: a comprehensive review of its botany, phytochemistry and pharmacology. Am J Chin Med 48:871–897. https://doi.org/10.1142/S0192415X20500421
Shao Z, Li L, Zheng Y, Gong Q, Ke CQ, Yao S, Zhang H, Tang C, Ye Y (2022) Anti-inflammatory sesquiterpenoid dimers from Artemisia atrovirens. Fitoterapia. https://doi.org/10.1016/j.fitote.2022.105199
Shinyuy LM, Loe GE, Jansen O, Mamede L, Ledoux A, Noukimi SF, Abenwie SN, Ghogomu SM, Souopgui J, Robert A, Demeyer K, Frederich M (2023) Secondary metabolites isolated from artemisia afra and artemisia annua and their anti-malarial, anti-inflammatory and immunomodulating properties—pharmacokinetics and pharmacodynamics: a review. Metabolites. https://doi.org/10.3390/metabo13050613
Soni R, Shankar G, Mukhopadhyay P, Gupta V (2022) A concise review on Artemisia annua L.: a major source of diverse medicinal compounds. Ind Crops Prod. https://doi.org/10.1016/j.indcrop.2022.115072
Su RX, Wu ZL, Wang YY, Dong HL, Dong HY, Li HL, Wang SM (2020) Lineariifolianoids M-O, three rare sesquiterpene lactone dimers inhibiting NO production from Inula lineariifolia. Fitoterapia 141:104454. https://doi.org/10.1016/j.fitote.2019.104454
Su L, Li T, Geng C, Ma Y, Huang X, Wang J, Zhang X, Chen J (2021a) Trimeric and dimeric sesquiterpenoids from Artemisia atrovirens and their cytotoxicities. Org Chem Front 8:1249–1256. https://doi.org/10.1039/d0qo01615b
Su L, Zhang X, Ma Y, Geng C, Huang X, Hu J, Li T, Tang S, Shen C, Gao Z, Zhang X, Chen JJ (2021b) New guaiane-type sesquiterpenoid dimers from Artemisia atrovirens and their antihepatoma activity. Acta Pharm Sin B 11:1648–1666. https://doi.org/10.1016/j.apsb.2020.12.006
Su LH, Li TZ, Ma YB, Geng CA, Huang XY, Zhang X, Gao Z, Chen JJ (2021c) Artematrovirenolides A-D and artematrolides S-Z, sesquiterpenoid dimers with cytotoxicity against three hepatoma cell lines from Artemisia atrovirens. Chin J Chem 40:104–114. https://doi.org/10.1002/cjoc.202100528
Su LH, Ma WJ, Ma YB, Li TZ, Geng CA, Dong W, He XF, Chen JJ (2023) Artemiprinolides A-M, thirteen undescribed sesquiterpenoid dimers from Artemisia princeps and their antihepatoma activity. Phytochemistry 211:113714. https://doi.org/10.1016/j.phytochem.2023.113714
Sun CP, Jia ZL, Huo XK, Tian XG, Feng L, Wang C, Zhang BJ, Zhao WY, Ma XC (2021) Medicinal inula species: phytochemistry, biosynthesis, and bioactivities. Am J Chin Med 49:315–358. https://doi.org/10.1142/S0192415X21500166
Tang JJ, Guo C, Peng XN, Guo XC, Zhang Q, Tian JM, Gao JM (2021) Chemical characterization and multifunctional neuroprotective effects of sesquiterpenoid-enriched Inula britannica flowers extract. Bioorg Chem 116:105389. https://doi.org/10.1016/j.bioorg.2021.105389
Thongnest S, Chawengrum P, Keeratichamroen S, Lirdprapamongkol K, Eurtivong C, Boonsombat J, Kittakoop P, Svasti J, Ruchirawat S (2019) Vernodalidimer L, a sesquiterpene lactone dimer from Vernonia extensa and anti-tumor effects of vernodalin, vernolepin, and vernolide on HepG2 liver cancer cells. Bioorg Chem 92:103197. https://doi.org/10.1016/j.bioorg.2019.103197
Tu Y (2016) Artemisinin-A gift from traditional Chinese medicine to the world (Nobel lecture). Angew Chem Int Ed Engl 55:10210–10226. https://doi.org/10.1002/anie.201601967
Turak A, Aisa HA (2022) Oxygen heterocyclic Diels-Alder-type sesquiterpenoid dimers from Vernonia anthelmintica. Phytochemistry 203:113386. https://doi.org/10.1016/j.phytochem.2022.113386
Tyagi R, Alam P, Rehman MT, Alajmi MF, Hussain A, Amin S, Mujeeb M, Mir SR (2020) A new cytotoxic dimeric sesquiterpene isolated from Inula racemosa Hook. f. (Root): in vitro and in silico analyses. Separations. https://doi.org/10.3390/separations8010002
Wang Q, Zhang T, Ke CQ, Tang C, Yao S, Lin L, Ye Y (2020) Sesquiterpene lactone dimers from Artemisia lavandulifolia inhibit interleukin-1beta production in macrophages through activating autophagy. Bioorg Chem 105:104451. https://doi.org/10.1016/j.bioorg.2020.104451
Wang YF, Fu Y, Ji YN, Shi NN, Francoise S, Lu XH, Gu YC, Shi QW, Huo CH (2022) Sesquiterpene lactone dimers from the fruit of Carpesium abrotanoides L. Phytochemistry 203:113389. https://doi.org/10.1016/j.phytochem.2022.113389
Wu J, Lu Y, Wong HNC, Peng X (2018a) Synthetic studies toward lindenane-type dimers via Diels–Alder reaction. Tetrahedron 74:6749–6760. https://doi.org/10.1016/j.tet.2018.10.005
Wu ZL, Wang JX, Chen LP, Dong HY, Li HL, Zhang WD (2018b) Five rare C32 sesquiterpene lactone dimers with anti-inflammation activity from Vladimiria souliei. Fitoterapia 125:117–122. https://doi.org/10.1016/j.fitote.2018.01.002
Wu ZL, Wang Q, Dong HY, Hui-Liang L, Wang SM, Zhang WD (2018c) Five rare dimeric sesquiterpenes exhibiting potential neuroprotection activity from Vladimiria souliei. Fitoterapia 128:192–197. https://doi.org/10.1016/j.fitote.2018.05.022
Wu ZL, Wang Q, Wang JX, Dong HY, Xu XK, Shen YH, Li HL, Zhang WD (2018d) Vlasoulamine A, a neuroprotective [3.2.2]cyclazine sesquiterpene lactone dimer from the roots of Vladimiria souliei. Org Lett 20:7567–7570. https://doi.org/10.1021/acs.orglett.8b03306
Wu JW, Tang CP, Yao S, Ke CQ, Ye Y (2021a) Three new carabrane sesquiterpenoid derivatives from the whole plant of Carpesium abrotanoides L. Chin J Nat Med 19:868–873. https://doi.org/10.1016/S1875-5364(21)60091-2
Wu RF, Zhou BD, Wang WQ, Chen T, Xu TT, Zhu SL, Xuan LJ (2021b) Neolinulicin A and B from Inula japonica and their anti-inflammatory activities. Fitoterapia 152:104905. https://doi.org/10.1016/j.fitote.2021.104905
Wu ZL, Wang Q, Fu L, Su RX, Sun ZS, Li HL (2021c) Vlasoulides A and B, a pair of neuroprotective C32 dimeric sesquiterpenes with a hexacyclic 5/7/5/5/(5)/7 carbon skeleton from the roots of Vladimiria souliei. RSC Adv 11:6159–6162. https://doi.org/10.1039/d1ra00075f
Wu RF, Wang WQ, Zhou BD, Wang Y, Li YD, Zhu SL, Xuan LJ (2022a) Anti-inflammatory sesquiterpene dimers and diterpenes from the aerial part of Inula japonica. J Asian Nat Prod Res 24:328–335. https://doi.org/10.1080/10286020.2021.1923012
Wu ZL, Li JY, Sun ZS, Yang YX, Xu XK, Li HL, Zhang WD (2022b) Vlasouliodes A-D, four new C30 dimeric sesquiterpenes exhibiting potential inhibition of MCF-7 cells from Vladimiria souliei. Fitoterapia 161:105234. https://doi.org/10.1016/j.fitote.2022.105234
Xue GM, Li XQ, Chen C, Chen K, Wang XB, Gu YC, Luo JG, Kong LY (2018) Highly oxidized guaianolide sesquiterpenoids with potential anti-inflammatory activity from Chrysanthemum indicum. J Nat Prod 81:378–386. https://doi.org/10.1021/acs.jnatprod.7b00867
Xue GM, Xue JF, Du K (2019a) Research progress on sesquiterpenoid dimers from Compositae. Nat Prod Res Dev 31:12. https://doi.org/10.16333/j.1001-6880.2019.12.024
Xue GM, Zhu DR, Han C, Wang XB, Luo JG, Kong LY (2019b) Artemisianins A-D, new stereoisomers of seco-guaianolide involved heterodimeric [4+2] adducts from Artemisia argyi induce apoptosis via enhancement of endoplasmic reticulum stress. Bioorg Chem 84:295–301. https://doi.org/10.1016/j.bioorg.2018.11.013
Xue GM, Zhu DR, Zhu TY, Wang XB, Luo JG, Kong LY (2019c) Lactone ring-opening seco-guaianolide involved heterodimers linked via an ester bond from Artemisia argyi with NO inhibitory activity. Fitoterapia 132:94–100. https://doi.org/10.1016/j.fitote.2018.12.004
Yang JY, Sanchez LM, Rath CM, Liu X, Boudreau PD, Bruns N, Glukhov E, Wodtke A, De Felicio R, Fenner A, Wong WR, Linington RG, Zhang L, Debonsi HM, Gerwick WH, Dorrestein PC (2013) Molecular networking as a dereplication strategy. J Nat Prod 76:1686–1699. https://doi.org/10.1021/np400413s
Yang YX, Wang JX, Li HL, Mo Q, Huang HY, Tao M, Luo Q, Liu H (2020) Five new C(17)/C(15) sesquiterpene lactone dimers from Carpesium abrotanoides. Fitoterapia 145:104630. https://doi.org/10.1016/j.fitote.2020.104630
Yang L, Yu H, Hou A, Man W, Wang S, Zhang J, Wang X, Zheng S, Jiang H, Kuang H (2021) A review of the ethnopharmacology, phytochemistry, pharmacology, application, quality control, processing, toxicology, and pharmacokinetics of the dried rhizome of Atractylodes macrocephala. Front Pharmacol 12:727154. https://doi.org/10.3389/fphar.2021.727154
Zhamilya A, Yuan J, Janar J, Tang CP, Ye Y (2019) Monomeric and dimeric sesquiterpene lactones from Artemisia heptapotamica. Chin J Nat Med 17:785–791. https://doi.org/10.1016/S1875-5364(19)30095-0
Zhan ZJ, Ying YM, Ma LF, Shan WG (2011) Natural disesquiterpenoids. Nat Prod Rep 28:594–629. https://doi.org/10.1039/c0np00050g
Zhang JP, Wang GW, Tian XH, Yang YX, Liu QX, Chen LP, Li HL, Zhang WD (2015) The genus Carpesium: a review of its ethnopharmacology, phytochemistry and pharmacology. J Ethnopharmacol 163:173–191. https://doi.org/10.1016/j.jep.2015.01.027
Zhang C, Wen R, Ma XL, Zeng KW, Xue Y, Zhang PM, Zhao MB, Jiang Y, Liu GQ, Tu PF (2018) Nitric oxide inhibitory sesquiterpenoids and its dimers from Artemisia freyniana. J Nat Prod 81:866–878. https://doi.org/10.1021/acs.jnatprod.7b00947
Zhang R, Tang C, Liu HC, Ren Y, Ke CQ, Yao S, Cai Y, Zhang N, Ye Y (2019) Tetramerized sesquiterpenoid ainsliatetramers A and B from Ainsliaea fragrans and their cytotoxic activities. Org Lett 21:8211–8214. https://doi.org/10.1021/acs.orglett.9b02909
Zhang WJ, Zhao ZY, Chang LK, Cao Y, Wang S, Kang CZ, Wang HY, Zhou L, Huang LQ, Guo LP (2021) Atractylodis Rhizoma: a review of its traditional uses, phytochemistry, pharmacology, toxicology and quality control. J Ethnopharmacol 266:113415. https://doi.org/10.1016/j.jep.2020.113415
Zhang Y, Hu YF, Li W, Xu GY, Wang KR, Li L, Luo H, Zou L, Wu JS (2022) Updates and advances on pharmacological properties of Taraxacum mongolicum Hand.-Mazz and its potential applications. Food Chem 373:131380. https://doi.org/10.1016/j.foodchem.2021.131380
Zhao W-Y, Yan J-J, Liu T-T, Gao J, Huang H-L, Sun C-P, Huo X-K, Deng S, Zhang B-J, Ma X-C (2020) Natural sesquiterpenoid oligomers: a chemical perspective. Eur J Med Chem. https://doi.org/10.1016/j.ejmech.2020.112622
Zheng ZQ, Wei WJ, Zhang J, Li HY, Xu K, Xu J, Tang B, Li Y, Gao K (2019) Heliaquanoids A-E, five sesquiterpenoid dimers from Inula helianthus-aquatica. J Org Chem 84:4473–4477. https://doi.org/10.1021/acs.joc.8b03284
Zhou N, Li JJ, Wu Y, Wang ZY, Wang X, Yin ZP, Wang XP, Liu YR, Shang XY (2022) New polymerized sesquiterpene lactones from Ainsliaea yunnanensis and their activity evaluation. Nat Prod Res 36:4862–4868. https://doi.org/10.1080/14786419.2021.1904924
Zhou X, Tang L, Xu Y, Zhou G, Wang Z (2014) Towards a better understanding of medicinal uses of Carthamus tinctorius L. in traditional Chinese medicine: a phytochemical and pharmacological review. J Ethnopharmacol 151:27–43. https://doi.org/10.1016/j.jep.2013.10.050
Zhuang K, **a Q, Zhang S, Maharajan K, Liu K, Zhang Y (2021) A comprehensive chemical and pharmacological review of three confusable Chinese herbal medicine-Aucklandiae radix, Vladimiriae radix, and Inulae radix. Phytother Res 35:6655–6689. https://doi.org/10.1002/ptr.7250
Acknowledgements
This work was supported by the National Natural Science Foundation of China (NO. 32100319), the Key Joint Project of Innovation and Application Development of Traditional Chinese Medicine of Chongqing Science and Technology Commission and Chongqing Health Commission (No. 2021ZY013997), the Fundamental Research Funds for the Central Universities, SWU (No. SWU-KR22052), Natural Science Foundation of Chongqing, China (No. CSTB2022NSCQ-MSX0878), open fund from State Key Laboratory of Southwestern Chinese Medicine Resources (No. SKLTCM202205), and Chongqing Innovative Training Program for University Students (S202310635373).
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FCM and ZW wrote this manuscript. SJP and GGZ collected and reorganized the literature data. GWW performed data analysis. JXM and AK revised the manuscript. ZHL and MC contributed to conception and design of the study. All authors contributed to manuscript revision, read, and approved the submitted version.
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Meng, F., Wang, Z., Peng, S. et al. Recent advances of sesquiterpenoid dimers from Compositae: distribution, chemistry and biological activities. Phytochem Rev (2024). https://doi.org/10.1007/s11101-023-09911-x
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DOI: https://doi.org/10.1007/s11101-023-09911-x