65 Result(s)
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Article
ScRNA-seq revealed the tumor microenvironment heterogeneity related to the occurrence and metastasis in upper urinary tract urothelial carcinoma
Metastasis is the greatest clinical challenge for UTUCs, which may have distinct molecular and cellular characteristics from earlier cancers. Herein, we provide single-cell transcriptome profiles of UTUC para ...
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Article
Frequency-domain analysis of membrane polarization in two-compartment model neurons with weak alternating electric fields
Transcranial alternating current stimulation (tACS) is widely used in studying brain functions and the treatment of neuropsychiatric diseases in a frequency-specific manner. However, how tACS works on neuronal...
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Article
Nanodosimetric quantity-weighted dose optimization for carbon-ion treatment planning
Dose verification of treatment plans is an essential step in radiotherapy workflows. In this work, we propose a novel method of treatment planning based on nanodosimetric quantity-weighted dose (NQWD), which c...
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Assessment of impaired consciousness using EEG-based connectivity features and convolutional neural networks
Growing electroencephalogram (EEG) studies have linked the abnormities of functional brain networks with disorders of consciousness (DOC). However, due to network data’s high-dimensional and non-Euclidean prop...
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Article
A functional gel polymer electrolyte based on PVDF-HFP/gelatin toward dendrite-free lithium metal batteries
The leakage of liquid electrolyte and the formation of lithium dendrites pose challenges to safety and stability of lithium metal batteries (LMBs). The appearance of gel polymer electrolyte (GPE) has obviously...
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A linearized modeling framework for the frequency selectivity in neurons postsynaptic to vibration receptors
Vibration is an indispensable part of the tactile perception, which is encoded to oscillatory synaptic currents by receptors and transferred to neurons in the brain. The A2 and B1 neurons in the drosophila bra...
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Prediction of hippocampal electric field in time series induced by TI-DMS with temporal convolutional network
Temporal interference deep-brain magnetic stimulation (TI-DMS) induces rhythmic electric field (EF) in the hippocampus to normalize cognitive function. The rhythmic time series of the hippocampal EF is essenti...
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Electric field effects on neuronal input–output relationship by regulating NMDA spikes
Evidence shows that the dendritic polarization induced by weak electrical field (EF) can affect the neuronal input–output function via modulating dendritic integration of AMPA synapses, indicating that the sup...
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Article
METTL3 facilitates stemness properties and tumorigenicity of cancer stem cells in hepatocellular carcinoma through the SOCS3/JAK2/STAT3 signaling pathway
Liver cancer stem cells (LCSCs) contribute to tumor recurrence and cancer cell proliferation in patients with hepatocellular carcinoma (HCC). METTL3-catalyzed m6A modification is relevant to the cancer stem cell ...
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Article
Open AccessPrognostic impact of tumor budding in rectal cancer after neoadjuvant therapy: a systematic review and meta-analysis
Tumor budding (TB) is a negative prognostic factor in colorectal cancer; however, its prognostic impact following neoadjuvant therapy for patients with rectal cancer remains unclear. This study aims to assess ...
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Open AccessA compendium of genetic regulatory effects across pig tissues
The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been established to develop a public resource of genetic regulatory variants in livestock, which is essential for linking genetic polymorphisms...
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Article
The novel CDK9 inhibitor, XPW1, alone and in combination with BRD4 inhibitor JQ1, for the treatment of clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) is a highly lethal malignancy with few therapeutic options. Cyclin‑dependent kinase 9 (CDK9), a potential therapeutic target of many cancers, has been recently observed ...
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Genetically predicted the causal relationship between gut microbiota and infertility: bidirectional Mendelian randomization analysis in the framework of predictive, preventive, and personalized medicine
Several studies have reported the association between gut microbiota and infertility; however, the causal association between them remains unclear. This study aimed to explore the causal relationship between g...
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Open AccessMacrophage Dectin-1 mediates Ang II renal injury through neutrophil migration and TGF-β1 secretion
Macrophage activation has been shown to play an essential role in renal fibrosis and dysfunction in hypertensive chronic kidney disease. Dectin-1 is a pattern recognition receptor that is also involved in chro...
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Open AccessEIF4A3-induced Circ_0001187 facilitates AML suppression through promoting ubiquitin-proteasomal degradation of METTL3 and decreasing m6A modification level mediated by miR-499a-5p/RNF113A pathway
Aberrant expression of circRNAs has been proven to play a crucial role in the progression of acute myeloid leukemia (AML); however, its regulatory mechanism remains unclear. Herein, we identified a novel circR...
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Evolution of brain network dynamics in early Parkinson’s disease with mild cognitive impairment
How mild cognitive impairment (MCI) is instantiated in dynamically interacting and spatially distributed functional brain networks remains an unexplored mystery in early Parkinson’s disease (PD). We applied a ...
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Aberrant temporal correlations of ongoing oscillations in disorders of consciousness on multiple time scales
Changes in neural oscillation amplitude across states of consciousness has been widely reported, but little is known about the link between temporal dynamics of these oscillations on different time scales and ...
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Open Access25(OH)Vitamin D and autism spectrum disorder: genetic overlap and causality
To identify whether there exists a genetic correlation and causal relationship between 25(OH)D and autism spectrum disorder (ASD).
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Article
In-plane grain boundary induced defect state in hierarchical NiCo-LDH and effect on battery-type charge storage
Domain boundaries are regarded as the effective active sites for electrochemical energy storage materials due to defects enrichment therein. However, layered double hydroxides (LDHs) tend to grow into single c...
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Open AccessSoluble PD-L1: a potential dynamic predictive biomarker for immunotherapy in patients with proficient mismatch repair colorectal cancer
Circulating soluble programmed death ligand 1 (sPD-L1) can negatively regulate T-cell function and serve as a prognostic or predictive marker in a variety of cancers. However, rare studies have evaluated the p...
