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Article
Open AccessRocuronium bromide suppresses esophageal cancer via blocking the secretion of C–X–C motif chemokine ligand 12 from cancer associated fibroblasts
Cancer associated fibroblasts (CAFs) communicate metabolically with tumor genesis and development. Rocuronium bromide (RB) is reported to exert certain inhibitory effect on tumor. Here, we investigate the role...
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Article
Open AccessNogo-B promotes angiogenesis and improves cardiac repair after myocardial infarction via activating Notch1 signaling
Nogo-B (Reticulon 4B) is reportedly a regulator of angiogenesis during the development and progression of cancer. However, whether Nogo-B regulates angiogenesis and post-myocardial infarction (MI) cardiac repa...
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Article
Structural Mechanical Characteristics of a Large Bolted Beam Reaction System and Its Modified Calculation Method
The primary error sources of engineering design for bolted beam reaction system with large size are mainly from the deformation of structure, mechanical behavior of connection joints. In addition, the simplifi...
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Article
Impact of posttranslational modifications in pancreatic carcinogenesis and treatments
Pancreatic cancer (PC) is a highly aggressive cancer, with a 9% 5-year survival rate and a high risk of recurrence. In part, this is because PC is composed of heterogeneous subgroups with different biological ...
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Article
Open AccessHuman Schlafen 5 regulates reversible epithelial and mesenchymal transitions in breast cancer by suppression of ZEB1 transcription
Human Schlafen 5 (SLFN5) has been reported to inhibit or promote cell invasion in tumours depending on their origin. However, its role in breast cancer (BRCA) is undetermined.
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Article
Genetic determinants of gestational diabetes mellitus: a case–control study in two independent populations
Genetic risk score (GRS) is more informative to identify the complicated associations between variants of genes and disease. Considering similar pathogenesis and shared genetic predispositions between gestatio...
