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  1. No Access

    Article

    RNAi screens identify HES4 as a regulator of redox balance supporting pyrimidine synthesis and tumor growth

    NADH/NAD+ redox balance is pivotal for cellular metabolism. Systematic identification of NAD(H) redox regulators, although currently lacking, would help uncover unknown effectors critically implicated in the coor...

    **g He, Aoxue Wang, Qin Zhao, Yejun Zou… in Nature Structural & Molecular Biology (2024)

  2. Article

    Open Access

    IGF1R-phosphorylated PYCR1 facilitates ELK4 transcriptional activity and sustains tumor growth under hypoxia

    The proline synthesis is importantly involved in tumor growth under hypoxia, while the underlying mechanism remains to be further investigated. Here we show that pyrroline-5-carpoxylate reductase-1 (PYCR1), di...

    Ke Zheng, Nannan Sha, Guofang Hou, Zhuyun Leng, Qin Zhao, Li Zhang… in Nature Communications (2023)

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  3. No Access

    Article

    The negative effect of G1958A polymorphism on MTHFD1 protein stability and HCC growth

    Methylenetetrahydrofolate dehydrogenase (MTHFD1), a key enzyme on the folate pathway, has been implicated in the tumor development of distinct types of cancers. The single nucleotide polymorphism (SNP) of 1958...

    Keqiang Rao, Ke Zheng, Qin Zhao, **g He, Bei Zhou, Guofang Hou… in Cellular Oncology (2023)

  4. Article

    Open Access

    SUMO1 modification of KHSRP regulates tumorigenesis by preventing the TL-G-Rich miRNA biogenesis

    MicroRNAs (miRNAs) are important regulators involved in diverse physiological and pathological processes including cancer. SUMO (small ubiquitin-like modifier) is a reversible protein modifier. We recently fou...

    Haihua Yuan, Rong Deng, **an Zhao, Ran Chen, Guofang Hou, Hailong Zhang… in Molecular Cancer (2017)

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  5. No Access

    Article

    QM-FISH analysis of the genes involved in the G1/S checkpoint signaling pathway in triple-negative breast cancer

    This study was conducted to analyze copy number alterations (CNAs) of the genes involved in the G1/S checkpoint signaling pathway of triple-negative breast cancer (TNBC) and to evaluate their clinical value in...

    Sheng Zhang, Yingbo Shao, Guofang Hou, **gchao Bai, Wei** Yuan… in Tumor Biology (2014)

  6. No Access

    Article

    Clinical pathological characteristics and prognostic analysis of diabetic women with luminal subtype breast cancer

    This study selected luminal-type breast cancer patients as the study subjects. The patients were divided into groups according to the presence of diabetes and the types of medication used, and the patients' cl...

    Yuanting **ao, Sheng Zhang, Guofang Hou, **aobei Zhang, **aomeng Hao… in Tumor Biology (2014)

  7. No Access

    Article

    Everolimus in combination with letrozole inhibit human breast cancer MCF-7/Aro stem cells via PI3K/mTOR pathway: an experimental study

    This study evaluated the effects of an mTOR inhibitor everolimus alone or in combination with letrozole on MCF-7/Aro (MCF-7 cells stably transfected with CYP19) in vitro and in vivo. In vitro studies, full-len...

    Yan Liu, **aobei Zhang, **g**g Liu, Guofang Hou, Sheng Zhang, ** Zhang in Tumor Biology (2014)

  8. No Access

    Article

    Clinical pathological characteristics and prognostic analysis of 1,013 breast cancer patients with diabetes

    The purpose of this study was to investigate the clinical, pathological, and prognostic characteristics of breast cancer patients with diabetes. In total, the study included 1,013 breast cancer patients with d...

    Guofang Hou, Sheng Zhang, **aobei Zhang, Pei Wang… in Breast Cancer Research and Treatment (2013)