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Article
PD-1–PD-L1 immunomodulatory pathway regulates cardiac regeneration
Adult hearts have inherently limited regenerative capabilities, such that injury results in lasting damage. The situation is different in neonatal mouse hearts, however, where a new study reveals a role for th...
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Article
Open AccessMending a broken heart with novel cardiogenic small molecules
Adult mammalian cardiomyocytes are unable to proliferate to regenerate lost tissue after heart injury. Du et al., reporting in Cell Stem Cell, employ a FUCCI- and MADM-based system to screen for small molecules c...
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Article
Open AccessVertebrate cardiac regeneration: evolutionary and developmental perspectives
Cardiac regeneration is an ancestral trait in vertebrates that is lost both as more recent vertebrate lineages evolved to adapt to new environments and selective pressures, and as members of certain species de...
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Article
Open AccessDefined factors to reactivate cell cycle activity in adult mouse cardiomyocytes
Adult mammalian cardiomyocytes exit the cell cycle during the neonatal period, commensurate with the loss of regenerative capacity in adult mammalian hearts. We established conditions for long-term culture of ...
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Chapter
Cellular Approaches to Adult Mammalian Heart Regeneration
Adult mammalian hearts lack significant regenerative potential, partially explaining why cardiomyopathies are a major cause of human death in the world. By contrast, adult lower vertebrates and neonatal mice c...
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Article
Heart repair by reprogramming non-myocytes with cardiac transcription factors
The adult mammalian heart possesses little regenerative potential following injury. Fibrosis due to activation of cardiac fibroblasts impedes cardiac regeneration and contributes to loss of contractile functio...
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Article
STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels
Stromal interacting molecule 1 (STIM1) is a Ca2+ sensor that conveys the Ca2+ load of the endoplasmic reticulum to store-operated channels (SOCs) at the plasma membrane. Here, we report that STIM1 binds TRPC1, TR...
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Article
STIM1 carboxyl-terminus activates native SOC, Icrac and TRPC1 channels
Receptor-evoked Ca2+ signalling involves Ca2+ release from the endoplasmic reticulum, followed by Ca2+ influx across the plasma membrane1. Ca2+ influx is essential for many cellular functions, from secretion to t...
