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Article
Open AccessPreconception folic acid supplementation for the prevention of birth defects: a prospective, population-based cohort study in mainland China
Folic acid supplementation is recommended for reducing the risk of birth defects. We aimed to assess the protective association of periconception folic acid supplements with birth defects in real-world setting.
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Article
Open AccessNeurodevelopmental risk and adaptation as a model for comorbidity among internalizing and externalizing disorders: genomics and cell-specific expression enriched morphometric study
Comorbidity is the rule rather than the exception for childhood and adolescent onset mental disorders, but we cannot predict its occurrence and do not know the neural mechanisms underlying comorbidity. We inve...
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Article
Comparison of clinical characteristics of first-episode thrombotic thrombocytopenic purpura and TTP-like syndrome: a retrospective cohort study in a level I hematology center in China
Comparing the characteristics of thrombotic thrombocytopenic purpura (TTP) and TTP-like syndrome patients at admission will allow early differentiation of TTP from TTP-like syndrome and help tailor initial tre...
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Article
Disrupted long-range gene regulations elucidate shared tissue-specific mechanisms of neuropsychiatric disorders
Neurological and psychiatric disorders have overlapped phenotypic profiles, but the underlying tissue-specific functional processes remain largely unknown. In this study, we explore the shared tissue-specifici...
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Article
Open AccessHemophagocytosis, hyper-inflammatory responses, and multiple organ damages in COVID-19-associated hyperferritinemia
Hyperferritinemia comes to light frequently in general practice. However, the characteristics of COVID-19-associated hyperferritinemia and the relationship with the prognosis were not well described. The retro...
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Article
Open AccessA global overview of genetically interpretable multimorbidities among common diseases in the UK Biobank
Multimorbidities greatly increase the global health burdens, but the landscapes of their genetic risks have not been systematically investigated.
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Article
Open AccessProminent coagulation disorder is closely related to inflammatory response and could be as a prognostic indicator for ICU patients with COVID-19
The new outbreak of Coronavirus Disease 2019 (COVID-19) has emerged as a serious global public health concern. A more in-depth study of blood coagulation abnormality is needed. We retrospectively analyzed 147 ...
