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Article
Open AccessIntegrated analysis of diverse cancer types reveals a breast cancer-specific serum miRNA biomarker through relative expression orderings analysis
Serum microRNA (miRNA) holds great potential as a non-invasive biomarker for diagnosing breast cancer (BrC). However, most diagnostic models rely on the absolute expression levels of miRNAs, which are suscepti...
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Article
Open AccessScreening prognostic markers for hepatocellular carcinoma based on pyroptosis-related lncRNA pairs
Pyroptosis is closely related to cancer prognosis. In this study, we tried to construct an individualized prognostic risk model for hepatocellular carcinoma (HCC) based on within-sample relative expression ord...
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Article
Open AccessConstruct of qualitative diagnostic biomarkers specific for glioma by pairing serum microRNAs
Serum microRNAs (miRNAs) are promising non-invasive biomarkers for diagnosing glioma. However, most reported predictive models are constructed without a large enough sample size, and quantitative expression le...
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Article
Open AccessIdentifying primary site of lung-limited Cancer of unknown primary based on relative gene expression orderings
Precise diagnosis of the tissue origin for metastatic cancer of unknown primary (CUP) is essential for deciding the treatment scheme to improve patients’ prognoses, since the treatment for the metastases is th...
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Article
Open AccessIdentification of molecular alterations in leukocytes from gene expression profiles of peripheral whole blood of Alzheimer’s disease
Blood-based test has been considered as a promising way to diagnose and study Alzheimer’s disease (AD). However, the changed proportions of the leukocytes under disease states could confound the aberrant expre...
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Article
Open AccessIdentifying disease-associated pathways in one-phenotype data based on reversal gene expression orderings
Due to the invasiveness nature of tissue biopsy, it is common that investigators cannot collect sufficient normal controls for comparison with diseased samples. We developed a pathway enrichment tool, DRFunc, to ...
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Article
Open AccessIdentifying Reproducible Molecular Biomarkers for Gastric Cancer Metastasis with the Aid of Recurrence Information
To precisely diagnose metastasis state is important for tailoring treatments for gastric cancer patients. However, the routinely employed radiological and pathologic tests for tumour metastasis have considerab...
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Article
Rank-based predictors for response and prognosis of neoadjuvant taxane-anthracycline-based chemotherapy in breast cancer
For neoadjuvant taxane and anthracycline-based chemotherapy for breast cancer, patients with pathological complete response (pCR) have a favorable prognosis compared with patients with residual disease (RD). A...
