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    Article

    Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence

    Prediabetes and Alzheimer’s disease both increase in prevalence with age. The former is a risk factor for the latter, but a mechanistic linkage between them remains elusive. We show that prediabetic serum hype...

    Hei-Man Chow, Meng Shi, Aifang Cheng, Yuehong Gao, Guimiao Chen… in Nature Neuroscience (2019)