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  1. No Access

    Article

    CEND1 deficiency induces mitochondrial dysfunction and cognitive impairment in Alzheimer’s disease

    Alzheimer’s disease (AD) is the most common form of neurodegenerative disease featured with memory loss and cognitive function impairments. Chronic mitochondrial stress is a vital pathogenic factor for AD and ...

    Wenting **e, Dong Guo, Jieyin Li, Lei Yue, Qi Kang… in Cell Death & Differentiation (2022)

  2. No Access

    Article

    Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence

    Prediabetes and Alzheimer’s disease both increase in prevalence with age. The former is a risk factor for the latter, but a mechanistic linkage between them remains elusive. We show that prediabetic serum hype...

    Hei-Man Chow, Meng Shi, Aifang Cheng, Yuehong Gao, Guimiao Chen… in Nature Neuroscience (2019)

  3. Article

    Open Access

    Cyclin-dependent kinase 5-mediated phosphorylation of chloride intracellular channel 4 promotes oxidative stress-induced neuronal death

    Oxidative stress can cause apoptosis in neurons and may result in neurodegenerative diseases. However, the signaling mechanisms leading to oxidative stress–induced neuronal apoptosis are not fully understood. ...

    Dong Guo, Wenting **e, Pan **ong, Huifang Li, Siqi Wang… in Cell Death & Disease (2018)

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  4. Article

    Open Access

    Expression of SHH signaling molecules in the develo** human primary dentition

    Our current knowledge on tooth development derives primarily from studies in mice. Very little is known about gene expression and function during human odontogenesis. Sonic Hedgehog (SHH) signaling has been de...

    Xuefeng Hu, Shuo Zhang, Guimiao Chen, Chensheng Lin… in BMC Developmental Biology (2013)

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