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Article
Open AccessDNMT3A clonal hematopoiesis-driver mutations induce cardiac fibrosis by paracrine activation of fibroblasts
Hematopoietic mutations in epigenetic regulators like DNA methyltransferase 3 alpha (DNMT3A), play a pivotal role in driving clonal hematopoiesis of indeterminate potential (CHIP), and are associated with unfa...
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Article
Open AccessIncreased susceptibility of human endothelial cells to infections by SARS-CoV-2 variants
Coronavirus disease 2019 (COVID-19) spawned a global health crisis in late 2019 and is caused by the novel coronavirus SARS-CoV-2. SARS-CoV-2 infection can lead to elevated markers of endothelial dysfunction a...
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Article
Open AccessPost-myocardial infarction heart failure dysregulates the bone vascular niche
The regulation of bone vasculature by chronic diseases, such as heart failure is unknown. Here, we describe the effects of myocardial infarction and post-infarction heart failure on the bone vascular cell comp...
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Article
Open AccessSingle cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction
Endothelial cells play a critical role in the adaptation of tissues to injury. Tissue ischemia induced by infarction leads to profound changes in endothelial cell functions and can induce transition to a mesen...
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Article
Open AccessMyocardial Bmp2 gain causes ectopic EMT and promotes cardiomyocyte proliferation and immaturity
During mammalian heart development, restricted myocardial Bmp2 expression is a key patterning signal for atrioventricular canal specification and the epithelial–mesenchyme transition that gives rise to the val...
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Article
Sequential Notch activation regulates ventricular chamber development
Ventricular chambers are essential for the rhythmic contraction and relaxation occurring in every heartbeat throughout life. Congenital abnormalities in ventricular chamber formation cause severe human heart d...
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Article
Open AccessNotch activation stimulates migration of breast cancer cells and promotes tumor growth
Dysregulated NOTCH receptor activity has been implicated in breast cancer but the mechanisms by which NOTCH contributes to transformation are not yet clear, as it has context-dependent effects on the propertie...
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Article
Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy
The Notch signaling pathway has a key role in sha** the develo** heart. Guillermo Luxán et al. identify two human mutations in the gene encoding the Notch pathway protein MIB1 that cause a type of cardiomyopa...
