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  1. Article

    Open Access

    Reconstruction the feedback regulation of amino acid metabolism to develop a non-auxotrophic l-threonine producing Corynebacterium glutamicum

    l-Threonine is an important feed additive with the third largest market size among the amino acids produced by microbial fermentation. The GRAS (generally regarded as safe) industrial workhorse Corynebacterium gl...

    Jianhang Liu, Jiao Liu, Jiajun Li, **aojia Zhao in Bioresources and Bioprocessing (2024)

  2. Article

    Open Access

    Knowledge map** of UMOD of English published work from 1985 to 2022: a bibliometric analysis

    UMOD is exclusively produced by renal epithelial cells. Recent genome-wide association studies (GWAS) suggested that common variants in UMOD gene are closely connected with the risk of CKD. However, a comprehe...

    Guannan Sun, Chao Liu, Chengcheng Song in International Urology and Nephrology (2024)

  3. Article

    Open Access

    Comparison of two surgical interventions for lumbar brucella spondylitis in adults: a retrospective analysis

    This retrospective study aimed to compare the clinical efficacy of the posterior procedure with the combined anterior and posterior procedure in the surgical management of lumbar Brucella spondylitis. From Jan...

    Dingyu Jiang, Liang Ma, **yang Wang, Zhenchao Xu, Guannan Sun in Scientific Reports (2023)

  4. Article

    Open Access

    CRISPR-assisted rational flux-tuning and arrayed CRISPRi screening of an l-proline exporter for l-proline hyperproduction

    Development of hyperproducing strains is important for biomanufacturing of biochemicals and biofuels but requires extensive efforts to engineer cellular metabolism and discover functional components. Herein, w...

    Jiao Liu, Moshi Liu, Tuo Shi, Guannan Sun, Ning Gao, **aojia Zhao in Nature Communications (2022)

  5. Article

    Retraction Note to: Robust Model Selection and Estimation for Censored Survival Data with High Dimensional Genomic Covariates

    The authors have retracted this article [1] because they found a fundamental mistake in the methodology that is not correctable at this time. This mistake is found in the methodology and the derivation of the ...

    Guorong Chen, Sijian Wang, Guannan Sun, Huanxue Pan in Acta Biotheoretica (2020)

  6. No Access

    Article

    RETRACTED ARTICLE: Robust Model Selection and Estimation for Censored Survival Data with High Dimensional Genomic Covariates

    When relating genomic data to survival outcomes, there are three main challenges that are the censored survival outcomes, the high-dimensionality of the genomic data, and the non-normality of data. We propose ...

    Guorong Chen, Sijian Wang, Guannan Sun, Huanxue Pan in Acta Biotheoretica (2019)

  7. Chapter and Conference Paper

    Brazil Soybean Area Estimation Based on Average Samples Change Rate of Two Years and Official Statistics of a Year Before

    Comprehensive, reliable and timely information of Brazil’s soybean area is necessary for China to make decisions on agricultural related problems. Spatial sampling method which combined remote sensing and samp...

    Kejian Shen, Weifang Li, Zhiyuan Pei in Computer and Computing Technologies in Agr… (2016)

  8. No Access

    Chapter and Conference Paper

    The Database Architecture Design of the Satellite Simulation Platform

    The database architecture is classified as database, database management system and users. The database management system is composed of several core modules named as internal mode, external mode, and map** ...

    Guannan Sun, Qipeng Hu, **n Lin in Theory, Methodology, Tools and Application… (2016)

  9. No Access

    Protocol

    Statistical Analysis of ChIP-seq Data with MOSAiCS

    Chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) is invaluable for identifying genome-wide binding of transcription factors and map** of epigenomic profiles. We present a stati...

    Guannan Sun, Dongjun Chung, Kun Liang, Sündüz Keleş in Deep Sequencing Data Analysis (2013)

  10. No Access

    Chapter

    Numerical Analysis on the Characteristics of Cavitation in the Variable Frequency Regulation of Centrifugal Pump

    In this paper, for a certain type of horizontal single-stage single-suction centrifugal pump, a 3d model based on Pro/e is constructed and imported into Fluent, using moving reference frame model and two-phase...

    Guannan Sun, Fanying Meng, **anghua Guo in Recent Advances in Computer Science and In… (2012)

  11. No Access

    Article

    Preparation of hollow silica microspheres with controlled shell thickness in supercritical fluids

    This article presents a novel route to prepare hollow silica microspheres with well-defined wall thickness by using cross-linked polystyrene (PS) microspheres as templates with the assistance of supercritical ...

    Guannan Sun, Zhimin Chen, Shanshan Wang, Linmei Li in Colloid and Polymer Science (2011)