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Article
Open AccessIntroducing or removing heparan sulfate binding sites does not alter brain uptake of the blood–brain barrier shuttle scFv8D3
The blood–brain barrier (BBB) greatly limits the delivery of protein-based drugs into the brain and is a major obstacle for the treatment of brain disorders. Targeting the transferrin receptor (TfR) is a strat...
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Article
Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations
PDZ domains are scaffolding modules in protein–protein interactions that mediate numerous physiological functions by interacting canonically with the C-terminus or non-canonically with an internal motif of pro...