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within Greta Hultqvist Remove this filter Science, Humanities and Social Sciences, multidisciplinary Remove this filter

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  1. Article

    Open Access

    Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood–brain barrier shuttle scFv8D3

    The blood–brain barrier (BBB) greatly limits the delivery of protein-based drugs into the brain and is a major obstacle for the treatment of brain disorders. Targeting the transferrin receptor (TfR) is a strat...

    Andrés de la Rosa, Nicole G. Metzendorf, Jamie I. Morrison… in Scientific Reports (2022)

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    Article

    Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations

    PDZ domains are scaffolding modules in protein–protein interactions that mediate numerous physiological functions by interacting canonically with the C-terminus or non-canonically with an internal motif of pro...

    Søren W. Pedersen, Stine B. Pedersen, Louise Anker… in Nature Communications (2014)