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  1. No Access

    Chapter

    Multimodal Methods for Knowledge Discovery from Bulk and Single-Cell Multi-Omics Data

    Multi-omics measurements (bulk and single-cell) are essential to depict the cellular states comprehensively and thus could derive a deep understanding of underlying mechanisms for cellular state changes in man...

    Yue Li, Gregory Fonseca, Jun Ding in Machine Learning Methods for Multi-Omics D… (2024)

  2. Article

    Open Access

    DOT1L regulates chamber-specific transcriptional networks during cardiogenesis and mediates postnatal cell cycle withdrawal

    Mechanisms by which specific histone modifications regulate distinct gene networks remain little understood. We investigated how H3K79me2, a modification catalyzed by DOT1L and previously considered a general ...

    Paola Cattaneo, Michael G. B. Hayes, Nina Baumgarten… in Nature Communications (2022)

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  3. Article

    Open Access

    Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations

    Cerebral cavernous malformations (CCMs) are dilated capillaries causing epilepsy and stroke. Inheritance of a heterozygous mutation in CCM3/PDCD10 is responsible for the most aggressive familial form of the disea...

    Janne Koskimäki, Dongdong Zhang, Yan Li… in Acta Neuropathologica Communications (2019)

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