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Article
Open AccessTranscriptome and chromatin landscape of iNKT cells are shaped by subset differentiation and antigen exposure
Invariant natural killer T cells (iNKT cells) differentiate into thymic and peripheral NKT1, NKT2 and NKT17 subsets. Here we use RNA-seq and ATAC-seq analyses and show iNKT subsets are similar, regardless of t...
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Protocol
Bacterial Infection Allows for Functional Examination of Adoptively Transferred Mouse Innate Lymphoid Cell Subsets
Innate lymphoid cells (ILCs) are important regulators of the early responses to infection at mucosal barriers, including the intestine. Recently, we have shown that specific ILC3 subsets protect against enteri...
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Article
Open AccessThe protein tyrosine kinase SYK regulates the alternative p38 activation in liver during acute liver inflammation
Two distinct p38 signaling pathways, classical and alternative, have been identified to regulate inflammatory responses in host defense and disease development. The role of alternative p38 activation in liver ...
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Article
Retinoic acid enhances lactoferrin-induced IgA responses by increasing betaglycan expression
Lactoferrin (LF) and retinoic acid (RA) are enriched in colostrum, milk, and mucosal tissues. We recently showed that LF-induced IgA class switching through binding to betaglycan (transforming growth factor-be...
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Article
TGF-β and BAFF derived from CD4+CD25+Foxp3+ T cells mediate mouse IgA isotype switching
TGF-β1 is generally accepted as the physiological IgA isotype switch factor. Nevertheless, it is unclear as to which cells in mucus-associated lymphoid tissue provide this cytokine to B cells. Regulatory T cel...
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Article
TGF-β1 stimulates mouse macrophages to express APRIL through Smad and p38MAPK/CREB pathways
A proliferation-inducing ligand (APRIL), a new TNF family member, supports B-cell survival and tumor cell proliferation. APRIL is secreted as a soluble protein by macrophages, dendritic cells and activated T c...
