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    Article

    CXCR5+PD-1++ CD4+ T cells colonize infant intestines early in life and promote B cell maturation

    Gastrointestinal infections are a major cause for serious clinical complications in infants. The induction of antibody responses by B cells is critical for protective immunity against infections and requires C...

    Ana Jordan-Paiz, Glòria Martrus, Fenja L. Steinert in Cellular & Molecular Immunology (2023)

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    A subset of HLA-DP molecules serve as ligands for the natural cytotoxicity receptor NKp44

    Natural killer (NK) cells can recognize virus-infected and stressed cells1 using activating and inhibitory receptors, many of which interact with HLA class I. Although early studies also suggested a functional im...

    Annika Niehrs, Wilfredo F. Garcia-Beltran, Paul J. Norman in Nature Immunology (2019)

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    Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1

    The activating NK cell receptor KIR3DS1 has been linked to the outcome of various human diseases, yet a ligand that would account for its biological effects has remained unknown. Altfeld and colleagues establi...

    Wilfredo F Garcia-Beltran, Angelique Hölzemer, Gloria Martrus in Nature Immunology (2016)