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  1. Article

    Open Access

    Quantitative transport map** of multi-delay arterial spin labeling MRI detects early blood perfusion alterations in Alzheimer’s disease

    Quantitative transport map** (QTM) of blood velocity, based on the transport equation has been demonstrated higher accuracy and sensitivity of perfusion quantification than the traditional Kety’s method-base...

    Yihao Guo, Liangdong Zhou, Yi Li, Gloria C. Chiang in Alzheimer's Research & Therapy (2024)

  2. Article

    Open Access

    [1-11C]-Butanol Positron Emission Tomography reveals an impaired brain to nasal turbinates pathway in aging amyloid positive subjects

    Reduced clearance of cerebrospinal fluid (CSF) has been suggested as a pathological feature of Alzheimer’s disease (AD). With extensive documentation in non-human mammals and contradictory human neuroimaging d...

    Neel H. Mehta, **uyuan Wang, Samantha A. Keil, Ke ** in Fluids and Barriers of the CNS (2024)

  3. Article

    Open Access

    Peripheral immune cell imbalance is associated with cortical beta-amyloid deposition and longitudinal cognitive decline

    Neuroinflammation is believed to be a key process in Alzheimer’s disease (AD) pathogenesis. Recently, the neutrophil-to-lymphocyte (NLR) and lymphocyte-to-monocyte ratios (LMR) have been proposed to be useful ...

    Neel H. Mehta, Liangdong Zhou, Yi Li, Laura Beth McIntire in Scientific Reports (2023)

  4. No Access

    Chapter

    Logopenic Variant Primary Progressive Aphasia

    Logopenic variant primary progressive aphasia, one of the three clinical variants of primary progressive aphasia, differs from other variants because it is typically associated with underlying Alzheimer’s dise...

    Michelle Roytman, Gloria C. Chiang in Hybrid PET/MR Neuroimaging (2022)

  5. No Access

    Chapter

    Creutzfeldt-Jakob Disease

    Creutzfeldt-Jakob disease (CJD) is a rare, fatal disease caused by prions, with rapidly progressive dementia leading to death in most patients within a year of clinical onset.

    Ilhami Kovanlikaya, Gloria C. Chiang in Hybrid PET/MR Neuroimaging (2022)

  6. No Access

    Chapter

    Dementia with Lewy Bodies

    Dementia with Lewy bodies is a progressive neurodegenerative α-synucleinopathy and the third most common cause of dementia, after Alzheimer’s disease and vascular dementia. Early diagnosis is useful for progno...

    Jenifer Pitman, Gloria C. Chiang in Hybrid PET/MR Neuroimaging (2022)

  7. No Access

    Chapter

    Behavioral Variant Frontotemporal Dementia

    Behavioral variant frontotemporal dementia (bvFTD) is among the most common types of nonvascular dementia and is as prevalent as Alzheimer’s disease (AD) among individuals with early-onset dementia. Due to its...

    Jeremy Ford, Gloria C. Chiang in Hybrid PET/MR Neuroimaging (2022)

  8. No Access

    Chapter

    Normal Pressure Hydrocephalus

    Idiopathic normal pressure hydrocephalus (iNPH) is one of the few reversible causes of cognitive impairment, and many patients can be effectively treated with surgical placement of a ventricular shunt. The cli...

    Ilhami Kovanlikaya, Gloria C. Chiang in Hybrid PET/MR Neuroimaging (2022)

  9. No Access

    Chapter

    The Role of Advanced Imaging in the Management of Brain Metastases

    Imaging plays a major role in the management of brain metastases, both to diagnose metastases in the pretreatment period and to differentiate recurrent metastasis from radiation change in the posttreatment per...

    Eaton Lin, Gloria C. Chiang in Central Nervous System Metastases (2020)