Page
%P
29 Result(s)
within
Giuseppe Del Giudice
-
Article
Open AccessMemory-like innate response to booster vaccination with MF-59 adjuvanted influenza vaccine in children
The pediatric population receives the majority of vaccines globally, yet there is a paucity of studies on the transcriptional response induced by immunization in this special population. In this study, we perf...
-
Article
Open AccessVaccination as a preventative measure contributing to immune fitness
The primary goal of vaccination is the prevention of pathogen-specific infection. The indirect consequences may include maintenance of homeostasis through prevention of infection-induced complications; trained...
-
Article
Open AccessCharacterization of potential biomarkers of reactogenicity of licensed antiviral vaccines: randomized controlled clinical trials conducted by the BIOVACSAFE consortium
Biomarkers predictive of inflammatory events post-vaccination could accelerate vaccine development. Within the BIOVACSAFE framework, we conducted three identically designed, placebo-controlled inpatient/outpat...
-
Article
Open AccessPharmacy-based interventions to increase vaccine uptake: report of a multidisciplinary stakeholders meeting
Despite the existence of efficacious vaccines, the burden of vaccine-preventable diseases remains high and the potential health benefits of paediatric, adolescent and adult vaccination are not being achieved d...
-
Article
Open AccessThe how’s and what’s of vaccine reactogenicity
Reactogenicity represents the physical manifestation of the inflammatory response to vaccination, and can include injection-site pain, redness, swelling or induration at the injection site, as well as systemic...
-
Article
Open AccessPlatformTM, a standards-based data custodianship platform for translational medicine research
Biomedical informatics has traditionally adopted a linear view of the informatics process (collect, store and analyse) in translational medicine (TM) studies; focusing primarily on the challenges in data integ...
-
Chapter
Administration of Vaccines: Current Process, New Technologies and Adjuvants
Vaccine formulations and administration have travelled a long path since the first vaccines were developed. Progress in pharmaceutical science has taught us a lot about tailoring vaccine formulations and route...
-
Article
Pattern Detection and Scaling Laws of Daily Water Demand by SOM: an Application to the WDN of Naples, Italy
In the present paper, a novel method is provided to detect significant daily consumption patterns and to obtain scaling laws to predict consumption patterns for groups of homogeneous users. The first issue rel...
-
Article
A Mixed Strategy Based on Self-Organizing Map for Water Demand Pattern Profiling of Large-Size Smart Water Grid Data
In the present paper a procedure is introduced to detect water consumption patterns within water distribution systems. The analysis is based on hourly consumption data referred to single-household flow meters,...
-
Article
Open AccessVaccination programs for older adults in an era of demographic change
Populations are aging worldwide. This paper summarizes some of the challenges and opportunities due to the increasing burden of infectious diseases in an aging population.
-
Article
Open AccessFighting against a protean enemy: immunosenescence, vaccines, and healthy aging
The progressive increase of the aged population worldwide mandates new strategies to ensure sustained health and well-being with age. The development of better and/or new vaccines against pathogens that affect...
-
Article
Influenza immunization elicits antibodies specific for an egg-adapted vaccine strain
Antibodies elicited by vaccination with influenza vaccine produced in eggs bind more strongly to the egg-adapted vaccine strain than to wild-type circulating strains.
-
Article
Open AccessSensitivity Analysis and Calibration of a Rainfall-Runoff Model with the Combined Use of EPA-SWMM and Genetic Algorithm
An integrated Visual Basic Application interface is described that allows for sensitivity analysis, calibration and routing of hydraulichydrological models. The routine consists in the combination of three fre...
-
Chapter
Inactivated and Adjuvanted Influenza Vaccines
Inactivated influenza vaccines are produced every year to fight against the seasonal epidemics of influenza. Despite the nonoptimal coverage, even in subjects at risk like the elderly, pregnant women, etc., th...
-
Article
Combined Effects of Parallel and Series Detention Basins for Flood Peak Reduction
A simple analytical method is proposed that allows a preliminary evaluation of the overall efficiency of a detention basin system for flood risk reduction in a specific target section. Solutions are provided b...
-
Article
Preliminary Estimate of Detention Basin Efficiency at Watershed Scale
Urban encroachment in natural floodplain areas and infrastructures interfering with watercourses have caused higher flood risks in lowland areas. In this context, detention basins have become a fundamental ins...
-
Article
Open AccessExpression of the Streptococcus pneumoniae pilus-1 undergoes on and off switching during colonization in mice
Streptococcus pneumoniae pili contribute to adherence and virulence. The regulation of pilus-1 expression is bistable, thus piliated strains contain a variable proportion of pilus-1-non-expressing bacteria. We in...
-
Article
Energy Production in Water Distribution Networks: A PAT Design Strategy
Pump operating as turbine (PAT) is an effective source of reducing the equipment cost in small hydropower plants. However, the manufacturers provide poor information on the PAT performance thus representing a ...
-
Chapter
Novel Strategies for Improved Vaccines for the Elderly: The Example of Influenza
Aging is characterized by a panoply of defects in various compartments of the immune system which render elderly individuals more susceptible to infectious diseases, and can profoundly affect the immunogenicit...
-
Book
