12 Result(s)
within
Giuseppe Del Giudice
English
-
Article
Open AccessMemory-like innate response to booster vaccination with MF-59 adjuvanted influenza vaccine in children
The pediatric population receives the majority of vaccines globally, yet there is a paucity of studies on the transcriptional response induced by immunization in this special population. In this study, we perf...
-
Article
Open AccessVaccination as a preventative measure contributing to immune fitness
The primary goal of vaccination is the prevention of pathogen-specific infection. The indirect consequences may include maintenance of homeostasis through prevention of infection-induced complications; trained...
-
Article
Open AccessCharacterization of potential biomarkers of reactogenicity of licensed antiviral vaccines: randomized controlled clinical trials conducted by the BIOVACSAFE consortium
Biomarkers predictive of inflammatory events post-vaccination could accelerate vaccine development. Within the BIOVACSAFE framework, we conducted three identically designed, placebo-controlled inpatient/outpat...
-
Article
Open AccessPharmacy-based interventions to increase vaccine uptake: report of a multidisciplinary stakeholders meeting
Despite the existence of efficacious vaccines, the burden of vaccine-preventable diseases remains high and the potential health benefits of paediatric, adolescent and adult vaccination are not being achieved d...
-
Article
Open AccessThe how’s and what’s of vaccine reactogenicity
Reactogenicity represents the physical manifestation of the inflammatory response to vaccination, and can include injection-site pain, redness, swelling or induration at the injection site, as well as systemic...
-
Article
Open AccessPlatformTM, a standards-based data custodianship platform for translational medicine research
Biomedical informatics has traditionally adopted a linear view of the informatics process (collect, store and analyse) in translational medicine (TM) studies; focusing primarily on the challenges in data integ...
-
Article
Open AccessVaccination programs for older adults in an era of demographic change
Populations are aging worldwide. This paper summarizes some of the challenges and opportunities due to the increasing burden of infectious diseases in an aging population.
-
Article
Open AccessFighting against a protean enemy: immunosenescence, vaccines, and healthy aging
The progressive increase of the aged population worldwide mandates new strategies to ensure sustained health and well-being with age. The development of better and/or new vaccines against pathogens that affect...
-
Article
Open AccessSensitivity Analysis and Calibration of a Rainfall-Runoff Model with the Combined Use of EPA-SWMM and Genetic Algorithm
An integrated Visual Basic Application interface is described that allows for sensitivity analysis, calibration and routing of hydraulichydrological models. The routine consists in the combination of three fre...
-
Article
Open AccessExpression of the Streptococcus pneumoniae pilus-1 undergoes on and off switching during colonization in mice
Streptococcus pneumoniae pili contribute to adherence and virulence. The regulation of pilus-1 expression is bistable, thus piliated strains contain a variable proportion of pilus-1-non-expressing bacteria. We in...
-
Article
Open AccessChallenges for vaccination in the elderly
The increased susceptibility of the elderly to infection presents a major challenge to public health services. An aging immune system is well documented as the cause of increased infection rates in elderly peo...
-
Article
Reduced antibody response to the repetitive sequence of the Plasmodium falciparum circumsporozoite protein in mice infected with Plasmodium yoelii blood forms
The immunogenicity of the carrier-free synthetic peptide, (NANP)40, from the repetitive region of the Plasmodium falciparum circumsporozoite (CS) protein was investigated in genetically responder mice (C57BL/6, H...
