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  1. Article

    Open Access

    The histone chaperone SPT2 regulates chromatin structure and function in Metazoa

    Histone chaperones control nucleosome density and chromatin structure. In yeast, the H3–H4 chaperone Spt2 controls histone deposition at active genes but its roles in metazoan chromatin structure and organisma...

    Giulia Saredi, Francesco N. Carelli… in Nature Structural & Molecular Biology (2024)

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  2. Article

    H4K20me0 recognition by BRCA1–BARD1 directs homologous recombination to sister chromatids

    Genotoxic DNA double-strand breaks (DSBs) can be repaired by error-free homologous recombination (HR) or mutagenic non-homologous end-joining1. HR supresses tumorigenesis1, but is restricted to the S and G2 phase...

    Kyosuke Nakamura, Giulia Saredi, Jordan R. Becker… in Nature Cell Biology (2019)

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    Article

    H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex

    We have a limited understanding of how cells mark and identify newly replicated genomic loci that have a sister chromatid; here, unmethylated K20 in the tail of new histone H4 is shown to serve as a signature ...

    Giulia Saredi, Hongda Huang, Colin M. Hammond, Constance Alabert… in Nature (2016)

  4. No Access

    Article

    A unique binding mode enables MCM2 to chaperone histones H3–H4 at replication forks

    Chromatin reassembly after replication requires recycling of old and deposition of new histones. Structural insights into how MCM2, part of the replicative helicase, interacts with H3–H4 suggest a function in ...

    Hongda Huang, Caroline B Strømme, Giulia Saredi… in Nature Structural & Molecular Biology (2015)