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Article
Open AccessSampling time-dependent artifacts in single-cell genomics studies
Robust protocols and automation now enable large-scale single-cell RNA and ATAC sequencing experiments and their application on biobank and clinical cohorts. However, technical biases introduced during sample ...
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Article
Open AccessSingle-cell transcriptomics unveils gene regulatory network plasticity
Single-cell RNA sequencing (scRNA-seq) plays a pivotal role in our understanding of cellular heterogeneity. Current analytical workflows are driven by categorizing principles that consider cells as individual ...
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Article
Open AccessIntegrated transcriptional analysis unveils the dynamics of cellular differentiation in the develo** mouse hippocampus
The ability to assign expression patterns to the individual cell types that constitute a tissue is a major challenge. This especially applies to brain, given its plethora of different, functionally interconnec...
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Article
Open AccessMonotonicity, frustration, and ordered response: an analysis of the energy landscape of perturbed large-scale biological networks
For large-scale biological networks represented as signed graphs, the index of frustration measures how far a network is from a monotone system, i.e., how incoherently the system responds to perturbations.
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Article
Influenza del digiuno prolungato e della dieta ipocalorica sui livelli plasmatici del somatotropo e dell'insulina nei soggetti obesi
In 12 soggetti affetti da obesità essenziale è stato studiato il comportamento della glicemia, dei NEFA plasmatici, dell'HGH e dell'insulina in condizioni di base ed in corso di prove dinamiche (carico orale d...
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Article
Comportamento dell'ormone somatotropo e dei NEFA plasmatici in corso di prove dinamiche nell'obesità essenziale
In 14 soggetti affetti da obesità essenziale ed in 5 soggetti normali sono stati studiati il comportamento della curva da carico orale di glucosio, della curva da carico i.v. di insulina e la risposta all'infu...
