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Open AccessPrediction of cardiovascular risk in patients with hepatocellular carcinoma receiving anti-angiogenic drugs: lessons from sorafenib
Antiangiogenics are associated with an increased risk of major adverse cardiac and cerebrovascular events (MACE). The identification of at-risk subjects is relevant in the case of hepatocellular carcinoma (HCC...
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Chapter
Liver Tumors Laser Ablation
Laser ablation (LA) is a useful tool to fight liver tumors. This minimally invasive technique is particularly useful in patients affected by hepatocellular carcinoma. In fact, in most of cases these patients a...
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Article
Metronomic capecitabine as second-line treatment for hepatocellular carcinoma after sorafenib discontinuation
Metronomic capecitabine (MC) is a well-tolerated systemic treatment showing promising results in one retrospective study, as second-line therapy after sorafenib failure, in patients with hepatocellular carcino...
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Validation of a Simple Scoring System to Predict Sorafenib Effectiveness in Patients with Hepatocellular Carcinoma
Sorafenib is recommended for the treatment of advanced-stage hepatocellular carcinoma (HCC). Nonetheless, it is expensive, effective in few patients, and may cause significant adverse effects. Therefore, accur...
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Impact of Diabetes on Outcomes of Sorafenib Therapy for Hepatocellular Carcinoma
Patients with diabetes are at increased risk of develo** hepatocellular carcinoma (HCC) and have a poorer prognosis as compared to non-diabetics when HCC occurs. Diabetics with non-HCC cancers are at higher ...
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Article
Impact of age on toxicity and efficacy of sorafenib-targeted therapy in cirrhotic patients with hepatocellular carcinoma
The incidence of hepatocellular carcinoma (HCC) is increasing worldwide and the proportion of older patients with HCC is expected to steadily rise in the next years. Sorafenib is the standard of care for patie...