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  1. No Access

    Article

    Next-generation characterization of the Cancer Cell Line Encyclopedia

    Large panels of comprehensively characterized human cancer models, including the Cancer Cell Line Encyclopedia (CCLE), have provided a rigorous framework with which to study genetic variants, candidate targets...

    Mahmoud Ghandi, Franklin W. Huang, Judit Jané-Valbuena, Gregory V. Kryukov… in Nature (2019)

  2. No Access

    Article

    Addendum: The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

    Jordi Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan… in Nature (2019)

  3. No Access

    Article

    SHP2 inhibition restores sensitivity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors

    Genomic and drug screens identify SHP2 blockade as a therapeutic approach for ALK-rearranged non-small cell lung cancers develo** resistance through ALK-mutant-independent mechanisms.

    Leila Dardaei, Hui Qin Wang, Manrose Singh, Paul Fordjour… in Nature Medicine (2018)

  4. No Access

    Article

    Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia

    Frank Stegmeier, Levi Garraway and colleagues apply a targeted mass spectrometry approach that measures level of histone modifications and identify a recurrent p.E1099K variant in NSD2 in acute lymphoblastic l...

    Jacob D Jaffe, Yan Wang, Ho Man Chan, **ghui Zhang, Robert Huether… in Nature Genetics (2013)

  5. Article

    Addendum: The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

    Jordi Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan… in Nature (2012)

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  6. No Access

    Article

    The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

    The Cancer Cell Line Encyclopedia presents the first results from a large-scale screen of some 947 cancer cell lines with 24 anticancer drugs, with the aim of identifying specific genomic alterations and gene ...

    Jordi Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan… in Nature (2012)

  7. No Access

    Article

    Advances in the preclinical testing of cancer therapeutic hypotheses

    The reduction in attrition rates of cancer therapeutics in the clinic requires robust translational strategies. In their Perspective, Caponigro and Sellers review historical and current uses of preclinical mod...

    Giordano Caponigro, William R. Sellers in Nature Reviews Drug Discovery (2011)

  8. No Access

    Article

    COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

    Clinical trials in melanoma patients carrying B-RAF gene mutations have shown promising results with the B-RAF kinase inhibitor PLX4032, but many patients go on to become resistant. Two papers now uncover possibl...

    Cory M. Johannessen, Jesse S. Boehm, So Young Kim, Sapana R. Thomas… in Nature (2010)

  9. Article

    Open Access

    Transcriptional transactivation by selected short random peptides attached to lexA-GFP fusion proteins

    Transcriptional transactivation is a process with remarkable tolerance for sequence diversity and structural geometry. In studies of the features that constitute transactivating functions, acidity has remained...

    Majid Abedi, Giordano Caponigro, Jiaxiang Shen, Steven Hansen… in BMC Molecular Biology (2001)

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  10. No Access

    Article

    An essential component of the decap** enzyme required for normal rates of mRNA turnover

    A MAJOR pathway of messenger RNA degradation in eukaryotic cells is initiated by shortening of the poly(A) tail, which, at least in yeast, triggers a decap** reaction, thereby exposing the mRNA to 5′→ 3′ de...

    Clare A. Beelman, Audrey Stevens, Giordano Caponigro, Thomas E. LaGrandeur… in Nature (1996)