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Article
Surface Plasmon Resonance and Biosensor Technology for Real-Time Molecular Diagnosis of β°39 Thalassemia Mutation
Background: Biospecific interaction analysis (BIA) employing surface plasmon resonance (SPR) and biosensor technologies is of interest in clinical genetics. However, few data are available on its...
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Article
Tissue-specific expression of theHLA-DRA gene in transgenic mice
Transgenic mice were produced containing a 33 kilobase (kb) DNA fragment encompassing the five exons and all the known regulatory regions of the class IIHLA-DRA gene. The transgene displayed regulated expression ...
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Chapter
Molecular Evolution of the Ha-ras-1 Oncogene: Relationship between DNA Methylation, Frequency of CpG Dinucleotides and Binding to the Sp1 Transacting Factor
One of the molecular events involved in the regulation of the expression of cellular oncogenes is the interaction between transcriptional factors and target DNA sequences present in the 5′ genomic portion1.
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Chapter
Ha-ras-1 Transfected Cells: Induction to Differentiation by Natural and Synthetic Retinoids
The in vitro activity of natural retinoids (retinoic acid and retinol) and new classes of synthetic analogues of retinoids on differentiation of chinese hamster fibroblasts transfected with either the normal (...