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Article
Reduction of oxidative stress and ornithine decarboxylase expression in a human prostate cancer cell line PC-3 by a combined treatment with α-tocopherol and naringenin
Differentiation of a human aggressive PC-3 cancer cell line was obtained, in a previous investigation, by the synergic effect of α-tocopherol (α-TOC) and naringenin (NG). This combined treatment induced apopto...
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Article
Evaluation of polyamines as marker of melanoma cell proliferation and differentiation by an improved high-performance liquid chromatographic method
The differentiation therapy is focused on the identification of new agents able to impair the proliferative and metastatic potential of cancer cells through the induction of differentiation. Although several m...
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Article
Increase in γ-globin mRNA content in human erythroid cells treated with angelicin analogs
The aim of the present study was to identify molecular analogs of angelicin (ANG) able to increase erythroid differentiation of K562 cells and expression of γ-globin genes in human erythroid precursor cells, w...
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Article
Open AccessUpstream stimulatory factors are involved in the P1 promoter directed transcription of the AbetaH-J-J locus
Alternative splicing of the locus AβH-J-J generates functionally distinct proteins: the enzyme aspartyl (asparaginyl) β-hydroxylase (AAH), truncated homologs of AAH with a role in calcium homeostasis humbug an...
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Chapter and Conference Paper
Antisense PNA and PNA-peptide Conjugates for the Modulation of β-globin Gene Splicing
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Article
Surface Plasmon Resonance and Biosensor Technology for Real-Time Molecular Diagnosis of β°39 Thalassemia Mutation
Background: Biospecific interaction analysis (BIA) employing surface plasmon resonance (SPR) and biosensor technologies is of interest in clinical genetics. However, few data are available on its...
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Article
Tissue-specific expression of theHLA-DRA gene in transgenic mice
Transgenic mice were produced containing a 33 kilobase (kb) DNA fragment encompassing the five exons and all the known regulatory regions of the class IIHLA-DRA gene. The transgene displayed regulated expression ...
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Article
Liposome mediated delivery of retinoids and aromatic polyamidines: Effects on growth of tumor cell lines
This paper describes the increase of antiproliferative activity toward tumor cell lines of liposome-delivered retinoids and aromatic polyamidines.
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Article
Methylation state of the human HLA-DRa gene in transgenic mice
We describe the tissue-specific expression and the reconstitution of the canonical methylation state of the human HLA-DRa gene in transgenic mice.
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Chapter
Molecular Evolution of the Ha-ras-1 Oncogene: Relationship between DNA Methylation, Frequency of CpG Dinucleotides and Binding to the Sp1 Transacting Factor
One of the molecular events involved in the regulation of the expression of cellular oncogenes is the interaction between transcriptional factors and target DNA sequences present in the 5′ genomic portion1.
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Chapter
Synthesys of Isoxazole and Isoxazoline Derivatives of Retinoids: Effects on Growth and Differentiation of Tumor Cells
We have studied the effects of several newly synthesized isoxazole and isoxazoline analogues of retinoids on induction of terminal differentiation and “in vitro” growth of tumor cell lines. Some of the tested ...
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Chapter
Ha-ras-1 Transfected Cells: Induction to Differentiation by Natural and Synthetic Retinoids
The in vitro activity of natural retinoids (retinoic acid and retinol) and new classes of synthetic analogues of retinoids on differentiation of chinese hamster fibroblasts transfected with either the normal (...
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Article
Inhibition of ‘in vitro’ tumor cell growth by aromatic polyamidines exhibiting antiproteinase activity
Aromatic polyamidines containing two, three or four benzamidine residues inhibit proteinase activity and proliferation of different human tumor cell lines, including leukemic (K562, HEL), melanoma (Colo 38) an...
