-
Article
Open AccessPublisher Correction: A metastasis map of human cancer cell lines
-
Article
Author Correction: Fatty acid synthesis is required for breast cancer brain metastasis
-
Article
Open AccessTargeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas
Immune checkpoint blockers (ICBs) have failed in all phase III glioblastoma (GBM) trials. Here, we show that regulatory T (Treg) cells play a key role in GBM resistance to ICBs in experimental gliomas. Targeti...
-
Article
Fatty acid synthesis is required for breast cancer brain metastasis
Brain metastases are refractory to therapies that control systemic disease in patients with human epidermal growth factor receptor 2-positive breast cancer and the brain microenvironment contributes to this th...
-
Article
Open AccessA metastasis map of human cancer cell lines
Most deaths from cancer are explained by metastasis, and yet large-scale metastasis research has been impractical owing to the complexity of in vivo models. Here we introduce an in vivo barcoding strategy that...
-
Article
The blood–brain barrier and blood–tumour barrier in brain tumours and metastases
For a blood-borne cancer therapeutic agent to be effective, it must cross the blood vessel wall to reach cancer cells in adequate quantities, and it must overcome the resistance conferred by the local microenv...
-
Article
Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium
The compression of brain tissue by a tumour mass is believed to be a major cause of the clinical symptoms seen in patients with brain cancer. However, the biological consequences of these physical stresses on ...
-
Article
Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models
Cytotoxic chemotherapy is an effective treatment for invasive breast cancer. However, experimental studies in mice also suggest that chemotherapy has pro-metastatic effects. Primary tumours release extracellul...
-
Article
Open AccessDual endothelin receptor inhibition enhances T-DM1 efficacy in brain metastases from HER2-positive breast cancer
The effective treatment of cerebral metastases from HER2-positive breast cancer remains an unmet need. Recent studies indicate that activated astrocytes and brain endothelial cells exert chemoprotective effect...
-
Article
A cerebellar window for intravital imaging of normal and disease states in mice
In this protocol, the skull overlying the cerebellum is removed and a window is applied, enabling intravital imaging to provide a detailed characterization of dynamic processes in this region of the mouse brain.
-
Article
Antibody-based therapies for the treatment of brain metastases from HER2-positive breast cancer: time to rethink the importance of the BBB?
-
Article
Open AccessEctodomain shedding of Limbic System-Associated Membrane Protein (LSAMP) by ADAM Metallopeptidases promotes neurite outgrowth in DRG neurons
IgLONs are members of the immunoglobulin superfamily of cell adhesion proteins implicated in the process of neuronal outgrowth, cell adhesion and subdomain target recognition. IgLONs form homophilic and hetero...
-
Article
Closing the gap: astrocytes and brain metastasis
Astrocytes are emerging as essential regulators of brain metastasis progression. In a current issue of Nature, Chen et al. identify a novel mechanism of astrocyte-carcinoma interaction and exploit vulnerabilities...
-
Protocol
Neurite Outgrowth and Growth Cone Collapse Assays to Assess Neuronal Responses to Extracellular Cues
The identification of molecular processes involved in regulating neurite outgrowth is an active area of interest for investigators studying neural development and regeneration. In vitro assays designed to meas...
