3 Result(s)
within
Gina M. Lenzi
Virology
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Article
CD81 association with SAMHD1 enhances HIV-1 reverse transcription by increasing dNTP levels
In this study, we report that the tetraspanin CD81 enhances human immunodeficiency virus (HIV)-1 reverse transcription in HIV-1-infected cells. This is enabled by the direct interaction of CD81 with the deoxyn...
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Article
Open AccessKinetic variations between reverse transcriptases of viral protein X coding and noncoding lentiviruses
Host SAM domain and HD domain-containing protein 1 (SAMHD1) suppresses reverse transcription kinetics of HIV-1 in nondividing cells such as macrophages by hydrolyzing and nearly depleting cellular dNTPs, which...
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Article
Open AccessdNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived macrophages
SAMHD1 degrades deoxyribonucleotides (dNTPs), suppressing viral DNA synthesis in macrophages. Recently, viral protein X (Vpx) of HIV-2/SIVsm was shown to target SAMHD1 for proteosomal degradation and led to el...
