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  1. No Access

    Article

    CD81 association with SAMHD1 enhances HIV-1 reverse transcription by increasing dNTP levels

    In this study, we report that the tetraspanin CD81 enhances human immunodeficiency virus (HIV)-1 reverse transcription in HIV-1-infected cells. This is enabled by the direct interaction of CD81 with the deoxyn...

    Vera Rocha-Perugini, Henar Suárez, Susana Álvarez… in Nature Microbiology (2017)

  2. Article

    Open Access

    Kinetic variations between reverse transcriptases of viral protein X coding and noncoding lentiviruses

    Host SAM domain and HD domain-containing protein 1 (SAMHD1) suppresses reverse transcription kinetics of HIV-1 in nondividing cells such as macrophages by hydrolyzing and nearly depleting cellular dNTPs, which...

    Gina M Lenzi, Robert A Domaoal, Dong-Hyun Kim, Raymond F Schinazi… in Retrovirology (2014)

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  3. Article

    Open Access

    dNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived macrophages

    SAMHD1 degrades deoxyribonucleotides (dNTPs), suppressing viral DNA synthesis in macrophages. Recently, viral protein X (Vpx) of HIV-2/SIVsm was shown to target SAMHD1 for proteosomal degradation and led to el...

    Joseph A Hollenbaugh, Sijia Tao, Gina M Lenzi, Sulryung Ryu, Dong-Hyun Kim… in Retrovirology (2014)

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  4. No Access

    Article

    Vesicular Integrity in Parkinson’s Disease

    The defining motor characteristics of Parkinson’s disease (PD) are mediated by the neurotransmitter dopamine (DA). Dopamine molecules spend most of their lifespan stored in intracellular vesicles awaiting rele...

    Shawn P. Alter, Gina M. Lenzi… in Current Neurology and Neuroscience Reports (2013)