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Article
Open AccessOTULIN protects the intestinal epithelium from apoptosis during inflammation and infection
The intestinal epithelium is a single cell layer that is constantly renewed and acts as a physical barrier that separates intestinal microbiota from underlying tissues. In inflammatory bowel disease (IBD) in h...
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Article
Open AccessHepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer
Glutamine synthetase (GS) activity is conserved from prokaryotes to humans, where the ATP-dependent production of glutamine from glutamate and ammonia is essential for neurotransmission and ammonia detoxificat...
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Article
ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation
The RNA-editing enzyme adenosine deaminase acting on RNA 1 (ADAR1) limits the accumulation of endogenous immunostimulatory double-stranded RNA (dsRNA)1. In humans, reduced ADAR1 activity causes the severe inflamm...
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Article
Open AccessMLKL deficiency in BrafV600EPten−/− melanoma model results in a modest delay of nevi development and reduced lymph node dissemination in male mice
Cancers acquire several capabilities to survive the multistep process in carcinogenesis. Resisting cell death is one of them. Silencing of the necroptosis initiator Ripk3 occurs in a wide variety of cancer types ...
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Article
Microbes exploit death-induced nutrient release by gut epithelial cells
Regulated cell death is an integral part of life, and has broad effects on organism development and homeostasis1. Malfunctions within the regulated cell death process, including the clearance of dying cells, can ...
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Article
Publisher Correction: Zeb2 drives invasive and microbiota-dependent colon carcinoma
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Zeb2 drives invasive and microbiota-dependent colon carcinoma
Colorectal cancer (CRC) is highly prevalent in Western society, and increasing evidence indicates strong contributions of environmental factors and the intestinal microbiota to CRC initiation, progression and ...
