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Article
Open AccessComponents of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology
Population-based biobanks with genomic and dense phenotype data provide opportunities for generating effective therapeutic hypotheses and understanding the genomic role in disease predisposition. To characteri...
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Article
A family of transposable elements co-opted into developmental enhancers in the mouse neocortex
The neocortex is a mammalian-specific structure that is responsible for higher functions such as cognition, emotion and perception. To gain insight into its evolution and the gene regulatory codes that pattern...
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Article
Human-specific loss of regulatory DNA and the evolution of human-specific traits
A computational survey of the human genome has identified more than 500 human-specific genomic deletions that remove sequences that are highly conserved between chimpanzees and other animals. These are genomic...
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Article
A distal enhancer and an ultraconserved exon are derived from a novel retroposon
Evidence from vertebrate genome sequences has shown that conserved noncoding regions significantly outnumber coding regions, and that these elements are mostly involved in gene regulation. The origins of these...