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Article
Fibroblast pyruvate carboxylase is required for collagen production in the tumour microenvironment
The aberrant production of collagen by fibroblasts is a hallmark of many solid tumours and can influence cancer progression. How the mesenchymal cells in the tumour microenvironment maintain their production o...
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Reference Work Entry In depth
Olanzapine
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Article
Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen
The majority of tumor-infiltrating T cells exhibit a terminally exhausted phenotype, marked by a loss of self-renewal capacity. How repetitive antigenic stimulation impairs T cell self-renewal remains poorly d...
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Article
A randomized, placebo-controlled trial of extended-release guanfacine in children with autism spectrum disorder and ADHD symptoms: an analysis of secondary outcome measures
In a prior report, we showed that extended-release guanfacine (GEXR) is safe and effective for children with autism spectrum disorder (ASD) accompanied by ADHD symptoms. Here, we examine the impact of GEXR on ...
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Article
Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity
A robust network of transcription factors and an open chromatin landscape are hallmarks of the naive pluripotent state. Recently, the acetyllysine reader Brd4 has been implicated in stem cell maintenance, but ...
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Article
The ubiquitin ligase Huwe1 regulates the maintenance and lymphoid commitment of hematopoietic stem cells
The longevity of hematopoietic stem cells requires strict regulation to prevent their exhaustion. Aifantis and colleagues show that the ubiquitin E3 ligase Huwe1 is needed to suppress the activity of the trans...
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Article
Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma
Sergey Nikolaev, Stylianos Antonarakis and colleagues analyze the genetic architecture of 293 basal cell carcinomas (BCCs) and characterize their mutational landscape. They observe UV signature mutations and i...
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Article
Erratum: TET1 is a tumor suppressor of hematopoietic malignancy
Nat. Immunol. 16, 653–662 (2015); published online 13 April 2015; corrected after print 17 June 2015 In the version of this article initially published, labels reading “5hmC gain” were incorrectly included bel...
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Article
TET1 is a tumor suppressor of hematopoietic malignancy
Methylation of DNA CpG motifs is modulated in part by the TET family of epigenetic regulators. Aifantis and colleagues show that loss of TET1 function biases hematopoiesis toward the B cell lineage and promote...
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Article
Cyclin C is a haploinsufficient tumour suppressor
Cyclin C was cloned as a growth-promoting G1 cyclin, and was also shown to regulate gene transcription. Here we report that in vivo cyclin C acts as a haploinsufficient tumour suppressor, by controlling Notch1 on...
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Article
Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia
T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a poor prognosis and no available targeted therapies; now two histone H3 lysine 27 demethylases, JMJD3 and UTX, are shown to hav...
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Article
Community Child Psychiatric Medication Experiences Measured by an Internet-Based, Prospective Parent Survey of Retail Pharmacy Customers
One thousand five hundred parents filling a psychiatric prescription for their 6–18 year old child with a multi-state retail pharmacy chain received a single mailed invitation to complete a detailed online sur...
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Article
Design and Subject Characteristics in the Federally-Funded Citalopram Trial in Children with Pervasive Developmental Disorders
The Studies to Advance Autism Research and Treatment Network conducted a randomized trial with citalopram in children with Pervasive developmental disorders (PDDs). We present the rationale, design and sample ...
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Article
An RNA gene expressed during cortical development evolved rapidly in humans
The developmental and evolutionary mechanisms behind the emergence of human-specific brain features remain largely unknown. However, the recent ability to compare our genome to that of our closest relative, th...
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Article
A distal enhancer and an ultraconserved exon are derived from a novel retroposon
Evidence from vertebrate genome sequences has shown that conserved noncoding regions significantly outnumber coding regions, and that these elements are mostly involved in gene regulation. The origins of these...
