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Article
Open AccessVascular endothelial growth factors and angiopoietins as new players in mastocytosis
Mastocytosis is a disorder characterized by the abnormal proliferation and/or accumulation of mast cells in different organs. More than 90% of patients with systemic mastocytosis have a gain-of-function mutati...
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Article
Open AccessNeutrophil extracellular traps and neutrophil-derived mediators as possible biomarkers in bronchial asthma
Neutrophils (PMNs) contain and release a powerful arsenal of mediators, including several granular enzymes, reactive oxygen species (ROS) and neutrophil extracellular traps (NETs). Although airway neutrophilia...
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Article
Open AccessGender dimorphism in IgA subclasses in T2-high asthma
Immunoglobulin A (Chan in J Allergy Clin Immunol 134:1394–14014e4, 2014), the second most abundant immunoglobulin in serum, plays an important role in mucosal homeostasis. In human serum, there are two subclas...
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Article
Open AccessAutoantibodies to IgE can induce the release of proinflammatory and vasoactive mediators from human cardiac mast cells
Mast cells are multifunctional immune cells with complex roles in tissue homeostasis and disease. Cardiac mast cells (HCMCs) are strategically located within the human myocardium, in atherosclerotic plaques, i...
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Article
Open AccessCorrection to: Is there a role for microbiome‑based approach in common variable immunodeficiency?
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Article
Open AccessIs there a role for microbiome-based approach in common variable immunodeficiency?
Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by low levels of serum immunoglobulins and increased susceptibility to infections, autoimmune disorders and cancer. CVID embr...