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  1. No Access

    Article

    3D high- and super-resolution imaging using single-objective SPIM

    Light-sheet microscopy using a single objective and micromirrors to orient the light sheet enables high- and super-resolution imaging of cells and embryos on a standard microscope.

    Remi Galland, Gianluca Grenci, Ajay Aravind, Virgile Viasnoff… in Nature Methods (2015)

  2. No Access

    Protocol

    Artificial Microniche Array with Spatially Structured Biochemical Cues

    We present here a method to create arrays of microcavities that can be differentially coated on their bottom, side, and top with different proteins. These cavities range in size from single cell to multicellul...

    Xumei Gao, Celine Stoecklin, Yue Zhang, Zhe Weng, Richard De Mets… in Cell-Based Microarrays (2018)

  3. No Access

    Article

    Expansion of patient-derived circulating tumor cells from liquid biopsies using a CTC microfluidic culture device

    This protocol describes a microfluidics approach for culturing liquid-biopsy-derived circulating tumor cell clusters to predict a patient's response toward various therapeutic strategies.

    Bee Luan Khoo, Gianluca Grenci, Ying Bena Lim, Soo Chin Lee… in Nature Protocols (2018)

  4. No Access

    Article

    Automated high-speed 3D imaging of organoid cultures with multi-scale phenotypic quantification

    Current imaging approaches limit the ability to perform multi-scale characterization of three-dimensional (3D) organotypic cultures (organoids) in large numbers. Here, we present an automated multi-scale 3D im...

    Anne Beghin, Gianluca Grenci, Geetika Sahni, Su Guo, Harini Rajendiran… in Nature Methods (2022)