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Morbihan Disease
With the first verifiable appearance of the nomenclature dated back to Robert Degos from France in 1973, Morbihan disease remains obscure regarding its epidemiology, etiopathogenesis, treatment, and prognosis....
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Chapter
Demodex Mites and Demodicosis
Human skin provides a favorable habitat for the growth of bacteria, yeasts, and mites. These are mostly commensals; they nourish themselves on and flourish in hair follicles, but curiously not within sweat gla...
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Chapter
Acne Classification and Disease Burden
Nosology does not rank high among the interests of acne researchers. Yet the lack of a common international standard for classifying and grading the severity of acne has been a distressing source of confusion ...
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Chapter
Acne and Nutrition
Daniel Turner (1667–1741) of London was the first to emphasize dietary restrictions for acne therapy. Joseph Jakob Plenck (1735–1807) of Vienna related the frequency of acne in young people to a rich diet. Sin...
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Chapter
Rosacea Pathogenesis
Multiple factors are involved in rosacea pathogenesis such as disturbed epidermal barrier function, cathelicidin antimicrobial peptide (CAMP)-mediated inflammation with inflammasome activation, aberrations of ...
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Chapter
Pilosebaceous Follicles: Structure, Biochemistry, and Function
For a deeper understanding of acne and sebaceous gland-related diseases, it is important to be familiar with the anatomy and physiology of sebaceous follicles. This chapter provides information about sebaceous...
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Chapter
Acne Pathogenesis
Four major factors are involved in the pathogenesis of acne: (1) increased sebum production with altered lipid composition, (2) metagenomic modifications of the P. acnes microbiome favoring P. acnes biofilm, (3) ...
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Chapter
Distinctive Acne Entities
We generally think of acne as a disease which begins in adolescence. Its presentation in the neonatal period or during infancy is disturbing but rarely serious. The following synopsis of acne shows the great s...
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Chapter
Acne-Associated Syndromes
Acne vulgaris can be considered as an inflammasomopathy of the sebaceous follicle, which is associated with increased seboglandular production of interleukin-1α (IL-1α) and IL-β1. Sebocytes have been demonstra...
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Chapter
Acne Therapy
This chapter provides a unifying model for acne therapy on the basis of transcriptomic regulation. Evidence from the literature will be presented that treatment-induced overexpression of the transcription fact...
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Chapter
Rosacea Epidemiology and Genetics
Rosacea is a chronic inflammatory skin condition that affects approximately 16 million US Americans. Considering the prevalence of rosacea in a US community setting, 6% of individuals had rosacea. Older, white...
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Chapter
Acne-Mimicking Diseases
In this chapter, dealing with a variety of diseases looking like acne, a number of terminologies are used in the international literature, including acneiform, acneform, acne-like, and acne mimicking, in an an...
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Chapter
Rosacea Clinic and Classification
Rosacea is a chronic disorder affecting the central parts of the face, characterized by frequent flushing, persistent erythema, and telangiectasia and interspersed with episodes of inflammation during which sw...
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Chapter
History of Acne and Rosacea
The roots of history were and still are the springs of our current knowledge and concepts in medicine. We owe this veneration to the forefathers of our specialty dermatology. To read, review, and understand th...
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Chapter
Acne Epidemiology and Genetics
There is substantial evidence that hereditary factors play an important role in acne pathogenesis. They enhance the risk for disease or aggravate its course and outcome and modify the time of onset, persistenc...
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Chapter
Acne Clinic: Morphogenesis
The comedo is the initial, primary lesion of acne. It is an impaction of corneocytes within sebaceous follicles. Comedones develop through the following stages.
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Chapter
Hidradenitis Suppurativa/Acne Inversa/Dissecting Terminal Hair Folliculitis
What we today name dissecting terminal hair folliculitis (DTHF) has lurked in the literature under several synonyms, namely, Velpeau’s disease (1839), Verneuil’s disease (1854), hidradenitis destruens suppurativa
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Chapter
Rosacea Therapy
Avoidance of rosacea trigger factors and appropriate skin care such as sunscreens and moisturizing agents are important first steps for rosacea treatment and prevention. Pharmacologic interventions range from ...
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Chapter
Acne Research Models
Genuine acne is a disease singular to man and practically does not occur in animals. There are a few exceptions to this rule. Except for minor forms in dogs and cats, acne does not occur spontaneously in any a...
